Managing Delayed Ejaculation from Long-Acting Psychiatric Injections - Psychiatry

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Drug side effects


Hello Dr.
Lin! I am currently receiving a long-acting injection called Seroquel, but I have recently noticed an issue with delayed ejaculation.
This problem has been bothering me for quite some time.
Could you please recommend a long-acting injection that does not lead to sexual dysfunction? Or do all long-acting injections cause sexual dysfunction?

Niming, 30~39 year old female. Ask Date: 2023/12/26

Dr. Lin Mianzhang reply Psychiatry


Hello: You are likely experiencing symptoms of hyperprolactinemia, which can be caused by many antipsychotic medications.
Among long-acting injectables, Abilify Maintena is less likely to have this side effect, but its effectiveness for you still needs to be evaluated by a physician.
Therefore, I recommend discussing your medication options with your doctor.
Wishing you peace and health.

Reply Date: 2023/12/26

More Info


Delayed ejaculation is a recognized side effect associated with many psychiatric medications, including long-acting injections such as the one you mentioned, which is likely an antipsychotic. The concern regarding sexual side effects, including delayed ejaculation, is significant for many patients undergoing treatment for psychiatric disorders. It is essential to address these concerns with your healthcare provider, as they can help you navigate the complexities of medication management while considering your sexual health.

Long-acting injections, particularly those used in the treatment of schizophrenia and bipolar disorder, can lead to various side effects, including sexual dysfunction. Medications like risperidone and olanzapine are known to potentially cause hyperprolactinemia, which can contribute to sexual side effects such as delayed ejaculation or even erectile dysfunction. The mechanism behind this is often related to the drug's impact on dopamine pathways in the brain, which play a crucial role in sexual function. When dopamine levels are disrupted, it can lead to decreased libido and sexual performance issues.

If you are experiencing delayed ejaculation, it is crucial to discuss this with your prescribing physician. They may consider several options:
1. Medication Adjustment: Your doctor might suggest switching to a different long-acting injection that has a lower incidence of sexual side effects. For instance, aripiprazole (Abilify) is often noted for having a more favorable sexual side effect profile compared to other antipsychotics. However, the efficacy of the medication for your specific condition must also be taken into account.

2. Combination Therapy: Sometimes, adding another medication can help mitigate the sexual side effects. For example, medications like bupropion, which is an antidepressant that tends to have fewer sexual side effects, might be considered as an adjunct to your current treatment.

3. Counseling and Support: Engaging in therapy or counseling can also be beneficial. Sexual dysfunction can be distressing, and discussing these feelings with a mental health professional can provide support and coping strategies.

4. Monitoring and Follow-Up: Regular follow-up appointments are essential to monitor your symptoms and adjust treatment as necessary. It is vital to maintain open communication with your healthcare provider about any side effects you experience.

It is important to note that not all long-acting injections will lead to sexual dysfunction, and individual responses to medications can vary widely. Some patients may tolerate certain medications well without experiencing significant side effects, while others may have a heightened sensitivity to these effects.

In conclusion, while delayed ejaculation can be a distressing side effect of long-acting psychiatric injections, it is not an insurmountable issue. By working closely with your healthcare provider, you can explore alternative medications or adjunct therapies that may alleviate this side effect while still effectively managing your psychiatric condition. Always prioritize open communication with your healthcare team to ensure that your treatment plan aligns with your overall well-being, including your sexual health.

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