Can You Take Fish Oil and Vitamin E While on Blood Thinners? - Cardiology

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Should individuals taking anticoagulants also take fish oil and vitamin E?


Hello, I am currently taking clopidogrel 75mg once daily and dipyridamole 25mg three times daily.
Can I take one capsule of NatureMade Vitamin E (400 IU (180 mg)) daily? Additionally, can I take one capsule of NatureMade Fish Oil (1000 mg (300 mg omega-3)) daily? Thank you very much for your response.

Luo Xiaohui, 50~59 year old female. Ask Date: 2023/12/30

Dr. Cai Guiqin reply Cardiology


We recommend that you discuss the above situation with your attending physician.
Wishing you good health.
Thank you!

Reply Date: 2023/12/30

More Info


When considering the use of fish oil and vitamin E while on blood thinners such as clopidogrel and dipyridamole, it is essential to understand the potential interactions and effects these supplements may have on your blood coagulation status.

Both fish oil and vitamin E are known for their blood-thinning properties. Fish oil, rich in omega-3 fatty acids (EPA and DHA), has been shown to reduce platelet aggregation, which can enhance the effects of anticoagulant medications. This means that while fish oil can be beneficial for cardiovascular health, it may also increase the risk of bleeding when taken in conjunction with blood thinners. The typical recommendation for omega-3 fatty acids is a daily intake of 2000-3000 mg, but this should be approached with caution if you are already on anticoagulant therapy.

Vitamin E, particularly in high doses, can also have anticoagulant effects. The recommended daily allowance for vitamin E is around 15 mg (22.4 IU), and while 400 IU (approximately 180 mg) is considered safe for most people, it may pose a risk for those on blood thinners. High doses of vitamin E can interfere with vitamin K metabolism, which is crucial for blood clotting, potentially leading to an increased risk of bleeding.

Given your current medication regimen of clopidogrel and dipyridamole, it is crucial to consult with your healthcare provider before adding any supplements, including fish oil and vitamin E. Your doctor can assess your individual health status, including any underlying conditions, and determine whether these supplements are appropriate for you. They may also monitor your blood coagulation parameters to ensure that your bleeding risk remains within a safe range.

In summary, while both fish oil and vitamin E have health benefits, their use in conjunction with blood thinners requires careful consideration and professional guidance. Always prioritize open communication with your healthcare provider regarding any supplements you wish to take, especially when managing conditions that require anticoagulation therapy. This approach will help ensure your safety and optimize your overall health outcomes.

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