Erythromycin Ointment and Its Potential Ear Toxicity - Otolaryngology

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Regarding the ototoxicity of erythromycin ophthalmic ointment?


Hello, I have used erythromycin eye ointment for up to a year, and recently I have been experiencing tinnitus.
I would like to ask again, since I stopped using the ointment a year ago, can ototoxic symptoms manifest after a year? Thank you.

Gou Qisi, 40~49 year old female. Ask Date: 2024/02/05

Dr. Zheng Jueyi reply Otolaryngology


Hello, it is unlikely.
There are many factors that can cause tinnitus, and it should not be related to the eye ointment.

Reply Date: 2024/02/05

More Info


Erythromycin ointment is an antibiotic that is primarily used for treating bacterial infections, particularly in the eyes and skin. It is a macrolide antibiotic that works by inhibiting bacterial protein synthesis, thus preventing the growth of bacteria. While it is generally considered safe for topical use, there are concerns regarding its potential side effects, including the risk of ototoxicity (ear toxicity).

In your case, you have used erythromycin ointment for an extended period of one year and are now experiencing tinnitus (ear ringing). It is important to note that ototoxicity is typically associated with systemic administration of certain medications, particularly those that are administered intravenously or orally, rather than topical applications. The risk of developing ototoxicity from topical erythromycin is exceedingly low, especially when used as directed.

The question of whether ototoxic symptoms can manifest long after the cessation of a medication is complex. Generally, if a drug causes ototoxicity, symptoms would typically present during the course of treatment or shortly after discontinuation. However, there are exceptions, and individual responses to medications can vary widely. Factors such as underlying health conditions, concurrent medications, and individual susceptibility can influence the onset of symptoms.

In your situation, it is crucial to consider other potential causes of tinnitus. Environmental factors, such as exposure to loud noises, stress, and even changes in air quality, can contribute to the development of tinnitus. Additionally, conditions such as ear infections, wax buildup, or even age-related hearing loss can also lead to similar symptoms.
Given that you have stopped using the erythromycin ointment for a year, it is unlikely that it is the direct cause of your current ear symptoms. However, if the tinnitus persists or worsens, it is advisable to consult an ear, nose, and throat (ENT) specialist for a thorough evaluation. They can perform a comprehensive examination, including hearing tests, to determine the underlying cause of your symptoms and recommend appropriate treatment options.

In summary, while erythromycin ointment is not typically associated with ototoxicity, individual responses to medications can vary. It is essential to explore other potential causes of your tinnitus and seek professional medical advice if symptoms persist. Early intervention can help manage any underlying conditions and improve your overall quality of life.

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