Questions Regarding Treatment of Multiple Myeloma
Hello Dr.
Hu,
My mother is 67 years old and has been diagnosed with multiple myeloma through spinal cord testing, with a high IgD level (6000-7000).
Other body metrics are mostly normal, with the only notable abnormality being anemia.
Additionally, my mother has a chronic rheumatic condition.
Following the doctor's treatment plan, she is currently taking Selinexor and receiving injections of Daratumumab, with the hope of pursuing autologous stem cell transplantation in the future.
She is currently in the first phase of treatment, approximately two weeks in.
My mother has noticeable tremors in her hands and feet, and she experiences weakness in her limbs, making it somewhat difficult for her to stand up (she has low muscle mass).
1.
I inquired about the tremors with the doctor, who indicated that they are not a side effect of the medication.
The doctor speculated that the tremors might be due to anemia combined with low muscle mass, leading to nerve atrophy.
Would methods such as foot baths to enhance peripheral blood circulation potentially improve the tremors, or is the shaking a result of a deficiency in certain elements, making such interventions less meaningful?
2.
I found a couple of articles online mentioning tremors as a side effect of Selinexor.
Is it possible that the tremors could be a side effect of Selinexor? If the medication is discontinued in the future, is there a chance that her condition might improve?
Thank you for your assistance.
Sam, 30~39 year old female. Ask Date: 2024/02/06
Dr. Hu Ziren reply Oncology
If it is caused by Sider, typically after 1-2 months of adapting to the medication treatment, symptoms will gradually improve.
If it does not affect daily life, it is recommended to simply monitor the situation.
Reply Date: 2024/02/06
More Info
Addressing concerns related to multiple myeloma treatment, particularly in the context of a patient's journey, is crucial for both the patient and their family. Your mother’s diagnosis of multiple myeloma, coupled with her existing health conditions such as chronic rheumatism and anemia, presents a complex clinical picture that requires careful management and monitoring.
1. Tremors and Weakness: The tremors your mother is experiencing, along with her reported weakness, can indeed be multifactorial. While her physician has indicated that these symptoms are not side effects of the medications (such as the combination of lenalidomide, known as "賽得," and bortezomib, referred to as "萬科"), it is essential to consider other contributing factors. Anemia can lead to fatigue and weakness, and low muscle mass can exacerbate these symptoms. The tremors may also be related to neurological factors, especially if there is any underlying nerve involvement due to her chronic conditions.
Engaging in activities that promote blood circulation, such as soaking her feet in warm water, may provide some symptomatic relief. Improved circulation can help alleviate discomfort and may enhance overall well-being. However, it is important to note that while such practices can be beneficial for relaxation and comfort, they may not directly address the underlying causes of the tremors. If the tremors persist, further evaluation by a neurologist may be warranted to rule out any neurological conditions.
2. Potential Side Effects of Medications: Regarding the potential side effects of lenalidomide, it is indeed documented that some patients may experience tremors as a side effect of this medication. While not all patients will experience this, it is a possibility that should be monitored. If the tremors are indeed linked to the medication, they may resolve after discontinuation or adjustment of the dosage. It is essential to maintain open communication with her healthcare team about any side effects she experiences, as they can provide tailored advice and adjustments to her treatment plan.
3. Nutritional Considerations: In terms of nutritional support, ensuring that your mother is receiving adequate nutrition is vital, especially since she has low muscle mass. A diet rich in protein can help support muscle health, and certain vitamins and minerals, such as vitamin D and calcium, are crucial for bone health, particularly in patients with multiple myeloma. Consulting with a dietitian who specializes in oncology can provide personalized dietary recommendations that align with her treatment plan.
4. Monitoring and Follow-Up: Regular follow-up appointments are essential to monitor her response to treatment and manage any side effects. Blood tests will help assess her hemoglobin levels and overall health status, guiding any necessary adjustments in her treatment regimen. If her symptoms worsen or new symptoms arise, it is crucial to inform her healthcare provider promptly.
5. Psychosocial Support: Lastly, the emotional and psychological impact of a cancer diagnosis and treatment can be significant. Encouraging your mother to engage in support groups or counseling can provide her with additional coping strategies and emotional support during this challenging time.
In summary, while some of your mother’s symptoms may not be directly related to her medications, it is essential to address all aspects of her health, including anemia, muscle mass, and overall well-being. Open communication with her healthcare team will be key in navigating her treatment journey effectively.
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