Low-Grade Dysplasia: What It Means for Your Health - Internal Medicine

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Low-grade dysplasia refers to a condition where there are abnormal changes in the cells of a tissue, but these changes are not severe enough to be classified as cancer. It is


Hello Dr.
Cheng: During the Lunar New Year, I suddenly experienced abdominal pain (just above the navel), along with nausea, black stools, decreased appetite, and fatigue.
After the holiday, I visited an internal medicine clinic, where the doctor prescribed medication and scheduled me for an upper endoscopy.
Since I did not receive anesthesia, I was fully aware during the procedure.
The doctor diagnosed me with a gastric ulcer and also performed a biopsy.
Upon my follow-up visit to review the results, the doctor informed me that there was no Helicobacter pylori infection, but there were signs of low-grade dysplasia.
The doctor mentioned that gastric cancer can progress from low-grade to moderate or high-grade dysplasia, so I would like to ask Dr.
Cheng what low-grade dysplasia means.

Mr. Hsieh, 30~39 year old female. Ask Date: 2024/03/01

Dr. Zhang Shixin reply Internal Medicine


Hello Mr.
Hsieh: Low-grade dysplasia refers to a stage where cells exhibit abnormal proliferation but have not yet transformed into cancer cells.
The causes of abnormal proliferation may be related to environmental factors (such as Helicobacter pylori, high salt or pickled diets, smoking, and alcohol consumption) or genetic factors (genes).
It is recommended that you follow the advice of the clinic's physician regarding the treatment and follow-up for your gastric ulcer.
Thank you for your inquiry!

Reply Date: 2024/03/01

More Info


Low-grade dysplasia is a term used to describe abnormal changes in the cells of a tissue, which can be an early indicator of potential cancer development. In the context of your situation, where you have been diagnosed with a gastric ulcer and subsequently found to have low-grade dysplasia in a biopsy, it is essential to understand the implications of this finding for your health.

Dysplasia is categorized based on the degree of abnormality observed in the cells. Low-grade dysplasia indicates that the cells show some atypical features but are not yet cancerous. This condition is often considered a precancerous state, meaning that while it is not cancer, it has the potential to progress to cancer if not monitored or treated appropriately. The risk of progression to higher grades of dysplasia or cancer can vary based on several factors, including the underlying cause of the dysplasia, the presence of other risk factors, and the overall health of the individual.

In your case, the absence of Helicobacter pylori, a common bacterium associated with gastric ulcers and stomach cancer, is a positive sign. However, the presence of low-grade dysplasia still warrants careful monitoring. Your doctor may recommend regular follow-up endoscopies and biopsies to keep an eye on the dysplastic changes. This is crucial because, as your doctor mentioned, low-grade dysplasia can progress to moderate or high-grade dysplasia, which is more concerning and has a higher likelihood of developing into gastric cancer.

It is also important to consider lifestyle and dietary factors that can influence gastric health. A diet rich in fruits, vegetables, and whole grains, along with adequate hydration, can support overall digestive health. Avoiding irritants such as alcohol, tobacco, and non-steroidal anti-inflammatory drugs (NSAIDs) can also be beneficial, as these substances can exacerbate gastric issues and potentially contribute to further dysplastic changes.

In addition to dietary modifications, managing stress is vital, as stress can impact digestive health and exacerbate symptoms associated with gastric ulcers. Engaging in stress-reducing activities such as yoga, meditation, or regular physical exercise can be helpful.

Lastly, it is crucial to maintain open communication with your healthcare provider. Discuss any new symptoms you experience, such as changes in appetite, weight loss, or persistent abdominal pain, as these could indicate changes in your condition that require further evaluation.

In summary, low-grade dysplasia is a significant finding that necessitates careful monitoring and management. While it is not cancer, it is a warning sign that should not be ignored. Regular follow-ups, lifestyle modifications, and a proactive approach to your health can help mitigate the risks associated with this condition. Always consult with your healthcare provider for personalized advice and treatment options tailored to your specific situation.

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