Your Blood Test Results: Cholesterol and WBC Concerns - Family Medicine

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Blood test report issues?


I recently received my lab report and have two questions.
The first issue is regarding my total cholesterol, which is 205, indicating it is slightly high.
My triglycerides are 115, which is normal, my HDL-C is 72.3, which is normal, and my LDL-C is 94.5, which is also normal.
However, I recall a formula: HDL + LDL + TG/5 = total cholesterol, and it seems to contradict my results.
Additionally, why is my total cholesterol elevated when all three components are normal? What measures should I take?
The second issue is that my white blood cell count (WBC) is low at only 4.1.
How can I improve this? Thank you, doctor.

Da Ke Sushi, 30~39 year old female. Ask Date: 2024/05/01

Dr. Ye Qianyu reply Family Medicine


Hello! "Total cholesterol is composed of esterified cholesterol (Cholesterol ester, approximately 70%) and free cholesterol (Free cholesterol, approximately 30%).
These two components are derived from four types of lipoproteins, including high-density lipoprotein (HDL), low-density lipoprotein (LDL), very low-density lipoprotein (VLDL), and chylomicrons.
The formula estimates VLDL as approximately TG/5; however, if chylomicrons are elevated, this formula may be inaccurate.
Based on your current values, they are still within a healthy range.
It is recommended to reduce the intake of high-calorie foods and engage in regular exercise.
The total white blood cell count is slightly low, and it is suggested that during your next examination, you also check the white blood cell differential to understand the neutrophil count."

Reply Date: 2024/05/01

More Info


Understanding your blood test results can be quite challenging, especially when it comes to interpreting cholesterol levels and white blood cell (WBC) counts. Let's break down your concerns regarding total cholesterol and WBC levels.


Cholesterol Levels
Your total cholesterol level is reported as 205 mg/dL, which is considered borderline high. The breakdown of your cholesterol levels shows that your triglycerides (TG) are at 115 mg/dL, which is within the normal range, and your HDL (high-density lipoprotein) is at 72.3 mg/dL, which is excellent as it is often referred to as "good" cholesterol. Your LDL (low-density lipoprotein) is at 94.5 mg/dL, which is also within the optimal range.

You mentioned a formula: HDL + LDL + TG/5 = Total Cholesterol. This formula is a simplified way to estimate total cholesterol, but it can sometimes yield results that do not match the direct measurement due to variations in individual lipid metabolism and the presence of other lipid components in the blood. The formula is primarily used for screening purposes and may not always reflect the exact total cholesterol level measured in a lab test.

Given that your HDL and LDL levels are normal, the primary concern is your total cholesterol being slightly elevated. Here are some steps you can take to manage your cholesterol levels:
1. Dietary Changes: Focus on a heart-healthy diet that includes plenty of fruits, vegetables, whole grains, and lean proteins. Reduce saturated fats found in red meat and full-fat dairy products, and eliminate trans fats found in many processed foods.

2. Increase Physical Activity: Regular exercise can help raise HDL cholesterol and lower LDL cholesterol. Aim for at least 150 minutes of moderate aerobic activity or 75 minutes of vigorous activity each week.

3. Weight Management: If you are overweight, losing even a small amount of weight can help improve your cholesterol levels.

4. Regular Monitoring: Keep track of your cholesterol levels with regular blood tests as recommended by your healthcare provider.


White Blood Cell Count
Your WBC count is reported as 4.1 x 10^3/µL, which is slightly below the normal range (typically around 4.5 to 11.0 x 10^3/µL). A low WBC count, known as leukopenia, can be caused by various factors, including:
- Infections: Some viral infections can temporarily decrease WBC counts.

- Bone Marrow Disorders: Conditions affecting the bone marrow can lead to decreased production of white blood cells.

- Autoimmune Disorders: Diseases where the immune system attacks the body can also lower WBC counts.

- Nutritional Deficiencies: Deficiencies in vitamins such as B12, folate, or copper can affect WBC production.

To improve your WBC count, consider the following:
1. Nutrition: Ensure you are consuming a balanced diet rich in vitamins and minerals. Foods high in vitamin B12 (like meat, fish, dairy), folate (like leafy greens, beans, and fortified cereals), and zinc (like nuts, seeds, and whole grains) can support healthy blood cell production.

2. Avoiding Toxins: Limit exposure to chemicals and toxins that can affect bone marrow function, such as certain medications and radiation.

3. Regular Check-ups: Follow up with your healthcare provider to monitor your WBC count and discuss any symptoms you may be experiencing.

4. Address Underlying Conditions: If your low WBC count is due to an underlying health issue, addressing that condition is crucial.

In conclusion, while your cholesterol levels and WBC count may raise some concerns, they can often be managed through lifestyle changes and regular monitoring. It is essential to work closely with your healthcare provider to develop a personalized plan that addresses your specific health needs. Regular follow-ups and open communication with your doctor will help ensure that you stay on track with your health goals.

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