Managing Recurrent Rheumatism: Impact of Traditional and Western Medicine - Internal Medicine

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Symptoms of recurrent rheumatic fever?


Hello, Doctor.
After experiencing persistent pain for three months, I was diagnosed with recurrent rheumatism.
One day I woke up with morning stiffness in both hands, but it disappeared after two days.
Later, my doctor prescribed quinine.
Before starting quinine, I had already been taking traditional Chinese medicine to manage my condition, so I thought it would be fine to stagger the doses.
I didn't realize I might need to stop the Chinese medicine first, and I've been taking both for almost a month now.
I am scheduled for blood tests soon to check the effects of quinine after one month of use.
I would like to know if taking both traditional Chinese medicine and quinine together will affect the efficacy of the quinine.
My intention was to use Chinese medicine to improve my constitution, but I forgot about the potential interactions.
Should I pause the Chinese medicine until I consult my primary physician?
Additionally, over the past month, the widespread migratory pain has disappeared (previously, it would shift from my fingers to wrists, elbows, and shoulders).
However, I have developed De Quervain's tenosynovitis in my left hand, and I've noticed that the painful area also experiences morning stiffness and feels less painful after moving.
My right hand, which initially had swelling in the index finger, has now spread to the thumb and middle finger, all on one side.
There is slight pain and tightness on the back of my hand, while the tightness in my left hand is only on the palm side.
In the past few days, the first and second joints of my right hand have shown noticeable morning stiffness, while my left hand has mild morning stiffness.
The joints of my right ring and middle fingers are significantly painful, but at the same time, my left index and little fingers have some discomfort (not pain).
I would like to know if this indicates a progression towards rheumatoid arthritis.
All my relevant markers are elevated, and my doctor has informed me that there is a high probability I may develop RA.
Since my follow-up appointment is still several days away, I wanted to inquire about this in advance.
Thank you.

Qin, 40~49 year old female. Ask Date: 2024/07/25

Dr. Gao Jiankai reply Internal Medicine


Hello, thank you for your inquiry.
Here are my responses:
1.
I will be undergoing a blood test in the next few days to check the status after taking quinine for a month.
I would like to know if the concurrent use of traditional Chinese medicine (TCM) and Western medicine will affect the efficacy of quinine? --> The impact is minimal, so there is no need to worry.
2.
My intention was to use TCM to improve my constitution, but I forgot that there might be potential interactions.
Should I pause the TCM until I consult with my attending physician? --> It is advisable to pause the TCM for now.
I also recommend discussing with your physician whether the concurrent use of TCM and Western medicine is appropriate.
For rheumatologists, unless prescribed by a TCM practitioner experienced in treating autoimmune diseases, we generally recommend not using TCM during the treatment phase.
3.
Additionally, after a month of medication, the widespread migratory pain has disappeared (previously, I experienced pain in my fingers, wrists, elbows, and shoulders).
However, I have developed "mother's thumb" in my left hand, and I have noticed that the painful areas experience morning stiffness and are less painful with movement.
My right hand, which initially had swelling in the index finger, has now increased to include the thumb and middle finger, all on one side.
There is slight pain and tightness on the back of the hand, while the left hand only has tightness on the palm side.
After a few days, the first and second joints of the right hand fingers showed significant morning stiffness, with mild morning stiffness in the left hand.
The right ring and middle fingers have noticeable pain, while the left index and little fingers have discomfort (not pain).
Should I be concerned that this indicates a progression towards rheumatoid arthritis? --> Typical rheumatoid arthritis is characterized by persistent and cumulative joint inflammation.
If more joints are becoming swollen and painful, along with elevated inflammatory markers, rheumatoid factor, and other related indices, it may indicate a gradual progression towards rheumatoid arthritis.
However, the medications available for treating this condition have advanced significantly, so there is no need to be overly anxious.
Once your physician examines your joints and assesses the changes in inflammatory markers, they will be able to provide a more accurate evaluation.

Sincerely, the Allergy, Immunology, and Rheumatology Department, Changhua Hospital, Ministry of Health and Welfare.

Reply Date: 2024/07/25

More Info


Managing recurrent rheumatism, particularly in the context of traditional and Western medicine, can be quite complex, especially when considering the potential interactions between different treatment modalities. Your situation, involving the use of quinine alongside traditional Chinese medicine (TCM), raises important questions about the efficacy and safety of combined therapies.

Firstly, it is essential to understand that both Western medicine and TCM have their unique mechanisms of action. Quinine, primarily used for its antimalarial properties, also has analgesic effects and is sometimes prescribed for conditions like nocturnal leg cramps. However, its use in rheumatism is less common and may be more about symptom management rather than addressing the underlying inflammatory processes. On the other hand, TCM often focuses on restoring balance within the body and may involve herbal remedies that can have anti-inflammatory properties.

When combining these two approaches, there is a risk of interactions that could either enhance or diminish the effectiveness of the treatments. For instance, certain herbs in TCM can affect liver enzymes that metabolize quinine, potentially altering its levels in the bloodstream. This could lead to either increased side effects or reduced therapeutic effects. Therefore, it is advisable to consult your healthcare provider before continuing both treatments simultaneously. They may recommend pausing the TCM until after your blood tests to ensure that the results accurately reflect the effects of the quinine alone.

Regarding your symptoms, the presence of morning stiffness and the pattern of pain you describe could suggest a progression towards a more inflammatory condition, such as rheumatoid arthritis (RA). The fact that you experience varying degrees of stiffness and pain in different joints, along with swelling, is characteristic of inflammatory arthritis. The fluctuation of symptoms, where pain moves from one joint to another, is also common in conditions like reactive arthritis or early RA.

Your elevated inflammatory markers and the physician's warning about the potential for developing RA are significant. It is crucial to monitor these symptoms closely and maintain open communication with your rheumatologist. They may suggest further diagnostic tests, such as rheumatoid factor (RF) or anti-citrullinated protein antibodies (anti-CCP), which can help confirm a diagnosis of RA.

In terms of management, it is vital to adopt a comprehensive approach. This may include:
1. Medication Management: If quinine is effective for your symptoms, it may be beneficial to continue it under medical supervision. If your condition progresses, your doctor may consider disease-modifying antirheumatic drugs (DMARDs) or biologics, which are more effective in managing inflammatory arthritis.

2. Physical Therapy: Engaging in physical therapy can help maintain joint function and reduce stiffness. A physical therapist can provide tailored exercises that promote flexibility and strength without exacerbating pain.

3. Lifestyle Modifications: Incorporating a balanced diet rich in anti-inflammatory foods, regular low-impact exercise, and stress management techniques can also contribute positively to your overall health and potentially reduce flare-ups.

4. Regular Monitoring: Regular follow-ups with your healthcare provider are essential to assess the effectiveness of your treatment plan and make necessary adjustments.

In conclusion, while the combination of TCM and Western medicine can be beneficial, it is crucial to approach this carefully and under the guidance of healthcare professionals. Your symptoms warrant close monitoring, and proactive management can help mitigate the risk of progression to more severe forms of arthritis. Always prioritize open communication with your healthcare team to ensure the best outcomes for your health.

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