Yellowing of the Eyes: Medication Side Effects and Solutions

Q: Yellowing of the Eyes: Medication Side Effects and Solutions

Dear Sam： Although the treatment for chronic urticaria may require a longer duration, with dietary and lifestyle adjustments over the course of a year, it should be manageable to a considerable extent. <br>I'm not sure if your physician has explained the reasons for such long-ter

Yellowing of the sclera?

Hello, I have been suffering from acne and chronic urticaria, and I have been receiving treatment from a dermatologist for about a year.
However, my condition has not improved; the acne continues to appear, and the chronic urticaria is still itchy.
If my skin is rubbed by external forces, it develops hives and large areas of erythema, accompanied by itching, which is quite distressing.
Recently, I have also noticed that the whites of my eyes have become yellow, my vision is somewhat blurred, and my eyes feel dry and sore when exposed to the wind.
A series of symptoms, especially the noticeable yellowing of the sclera, has left me worried and confused.
What is happening to me? Below is the prescription from my dermatologist:
- MINOCIN CAPSULES 50 mg, take 2 times a day orally
- METISONE, take 2 times a day orally
- PLOKON, take 2 times a day orally
- BENZOYL PEROXIDE, apply 2 times a day topically
- DIFFERIN, apply 2 times a day topically
I would like to ask if it is feasible to take these medications long-term? Could long-term use of these medications cause the noticeable yellowing of the sclera? If not, what condition could be causing the yellowing of the sclera? Are there any remedial treatments available? Please help clarify my concerns! Thank you.

sam, 30~39 year old female. Ask Date: 2004/08/13

Dr. Liao Lingmei reply Pharmacology

Dear Sam: Although the treatment for chronic urticaria may require a longer duration, with dietary and lifestyle adjustments over the course of a year, it should be manageable to a considerable extent.
I'm not sure if your physician has explained the reasons for such long-term medication; please discuss the treatment plan and medications during your next appointment.
The prescribed medications include MINOCIN 50MG for oral use, BENZOYL PEROXIDE and DIFFERIN for topical use, which are for the treatment of acne, while METISONE and PLOKON are for urticaria.

While discussing each medication individually may not present any issues, from a pharmacist's perspective, I would suggest that you first consider whether the existing untreated conditions (acne and chronic urticaria) could be a result of the side effects of the long-term medications you are taking.
METISONE is a corticosteroid, and long-term use can lead to acne.
DIFFERIN may cause a rash upon initial use, and although the side effects of long-term MINOCIN use were not mentioned in your content, it can be hepatotoxic in patients with compromised kidney function (symptoms may include skin itching or jaundice).
Even if not taken long-term, MINOCIN has been reported to cause skin rashes or peeling (though the incidence is quite low).
It is uncertain whether there is a cross-reaction contributing to the lack of improvement in your condition.
You may want to discuss with your physician the possibility of these being medication side effects (such as discontinuing or substituting certain medications, which can be determined by your physician).
After that, it may be necessary to consider liver and kidney function tests or seek medical attention for any eye issues.
Wishing you a swift resolution and good health.

Reply Date: 2004/08/13

More Info

Yellowing of the eyes, or scleral icterus, can be a concerning symptom and may indicate underlying health issues. In your case, it is essential to consider the medications you are taking and their potential side effects, as well as other possible causes for the yellowing of your eyes.

The medications you mentioned, including Minocin (minocycline), Metisone (a corticosteroid), and Plokon (likely a combination of medications for skin conditions), can have various side effects. Minocycline, for instance, is known to cause skin pigmentation changes and can lead to other systemic effects, although yellowing of the eyes is not a common side effect. Corticosteroids like Metisone can also have multiple effects on the body, including potential impacts on liver function, which could lead to jaundice (yellowing of the skin and eyes) if liver function is compromised.

The yellowing of the eyes could also be due to several other factors unrelated to your medications. These include:
1. Liver Dysfunction: Conditions affecting the liver, such as hepatitis, cirrhosis, or bile duct obstruction, can lead to an accumulation of bilirubin in the blood, causing the sclera to appear yellow.

2. Hemolysis: Increased breakdown of red blood cells can lead to elevated bilirubin levels, resulting in jaundice.

3. Gallbladder Issues: Problems with the gallbladder, such as gallstones, can also lead to yellowing of the eyes.

4. Other Medical Conditions: Conditions such as pancreatic disease or certain infections can also lead to jaundice.

Given your symptoms of yellowing eyes, blurred vision, and dry, sore eyes, it is crucial to consult with a healthcare professional. An ophthalmologist can evaluate your eye health, while a primary care physician or a hepatologist can assess your liver function and overall health.

In terms of management, here are some recommendations:
1. Medical Evaluation: Schedule an appointment with your healthcare provider to discuss your symptoms. They may recommend blood tests to check liver function, bilirubin levels, and other relevant parameters.

2. Medication Review: Discuss with your dermatologist or prescribing physician the possibility of side effects from your current medications. They may consider adjusting your treatment plan if they suspect the medications are contributing to your symptoms.

3. Hydration and Eye Care: Ensure you are well-hydrated, as dehydration can exacerbate dry eyes. Consider using artificial tears or lubricating eye drops to alleviate dryness and discomfort.

4. Diet and Lifestyle: A balanced diet rich in antioxidants (fruits and vegetables) can support overall health, including liver function. Avoid alcohol and other substances that can stress the liver.

5. Follow-Up: Regular follow-ups with your healthcare provider are essential to monitor your skin condition and any potential side effects from medications.

In summary, while the medications you are taking may have side effects, the yellowing of your eyes could indicate a more serious underlying issue that requires further investigation. It is vital to seek medical advice promptly to determine the cause and appropriate treatment for your symptoms.

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