Kidney Function Tests: Interpreting Abnormal Results - Internal Medicine

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Kidney function tests


I recently received my health check report.
Kidney examination: BUN=13 is normal, but creatinine=2.4 indicates an abnormal condition.
Gallbladder examination: total bilirubin (T-bil)=1.6 is abnormal, while direct bilirubin (d-bil)=0.3 is normal.
Urinalysis: all routine urine tests are normal except for a positive OB.
Liver function tests (SGOT and SGPT) are normal, and abdominal ultrasound is normal.
I wonder if this indicates any precursor to a disease? Additionally, the day before the health check, I visited a doctor for gastrointestinal dysfunction and took medication (in the evening), and then I fasted for over eight hours before the health check.
I am unsure if this could have affected the results.

so, 20~29 year old female. Ask Date: 2004/12/23

Dr. Cai Zonglong reply Internal Medicine


Hello, a creatinine level of 2.4 indicates abnormal kidney function.
There are many causes for kidney dysfunction, but your normal urine test results help rule out glomerulonephritis and interstitial nephritis.
The remaining differential diagnoses primarily include: 1.
Residual renal insufficiency from previous acute tubular necrosis 2.
Renal insufficiency due to hypercalcemia 3.
Renal insufficiency caused by bone marrow disorders.
It is still recommended to follow up with a nephrologist.
This response is provided on behalf of Dr.
Wang Wei-Jie from the nephrology department.

Reply Date: 2004/12/23

More Info


Interpreting kidney function tests can be quite complex, especially when faced with abnormal results. In your case, the report indicates a BUN (Blood Urea Nitrogen) level of 13, which is within the normal range, but a creatinine level of 2.4, which is significantly elevated. This discrepancy raises concerns about your kidney function.

Creatinine is a waste product generated from muscle metabolism and is typically filtered out of the blood by the kidneys. When kidney function declines, creatinine levels in the blood rise. A normal creatinine level generally ranges from about 0.6 to 1.2 mg/dL, depending on various factors including age, sex, and muscle mass. A level of 2.4 mg/dL indicates that your kidneys are not filtering waste effectively, which could suggest acute or chronic kidney disease.

The BUN level, while normal, can sometimes be misleading. BUN can be influenced by factors such as hydration status, protein intake, and liver function. In your case, the normal BUN level alongside the elevated creatinine suggests that the kidneys are struggling to filter waste, but the body is still managing to maintain a normal urea level, possibly due to adequate hydration or dietary factors.

Additionally, you mentioned that your urine test showed a positive result for occult blood (OB), which can indicate the presence of blood in the urine. This could be due to various reasons, including urinary tract infections, kidney stones, or more serious conditions such as glomerulonephritis or tumors. The fact that other routine urine tests were normal is somewhat reassuring, but the presence of blood should be investigated further.

Your liver function tests (SGOT and SGPT) being normal is a positive sign, as it suggests that your liver is functioning well, and the elevated creatinine is likely not related to liver dysfunction. The abdominal ultrasound being normal also rules out significant structural abnormalities in the kidneys or gallbladder.

Regarding your concern about the medications you took prior to the health check, certain medications can indeed affect kidney function. For example, non-steroidal anti-inflammatory drugs (NSAIDs) and some antibiotics can lead to acute kidney injury, especially if taken inappropriately or in the presence of dehydration. If you had gastrointestinal issues and were on medication, it’s possible that dehydration could have contributed to the elevated creatinine levels.

Given these findings, it is crucial to follow up with a healthcare provider, preferably a nephrologist, who can conduct further tests to determine the underlying cause of the elevated creatinine and the presence of blood in the urine. They may recommend additional tests such as a urine protein test, imaging studies, or even a kidney biopsy if necessary.

In summary, while your BUN level is normal, the elevated creatinine level and positive urine occult blood test warrant further investigation. It is essential to address these abnormalities promptly to prevent potential progression of kidney disease. Regular monitoring and a comprehensive evaluation of your kidney function will be key in managing your health moving forward.

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