Unexplained Fever: Sudden High Temperatures and Symptoms - Internal Medicine

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Sudden onset of fever... unknown cause?


Hello Doctor, I would like to ask you...
Two nights ago, I suddenly developed a fever of about 38-39.5 degrees Celsius.
My temperature fluctuated, and I experienced some lower back pain, overall weakness, and occasionally felt like I was about to faint.
Last night, I went to see a doctor and received two injections, which helped reduce the fever, but my temperature is still somewhat unstable, ranging between 38-39 degrees Celsius.
I don't often catch colds (1-2 times a year), but when I do, I immediately develop a fever, although I don't have a sore throat, runny nose, or cough—there are no warning signs.
Throughout the years, the doctors I have seen have been unable to determine the cause of my unexplained fevers, but ultimately, after receiving injections, the fever subsides.
I would like to ask the doctor if I need to undergo any further tests.
Thank you, Doctor.

Xiao Xin, 20~29 year old female. Ask Date: 2005/01/19

Dr. Yang Hongzhi reply Internal Medicine


If a fever persists for several days without any cold symptoms, it may be necessary to consider some diagnostic tests.
The specific tests to be conducted should be determined by a physician's physical examination, focusing on areas where an infection is suspected.
In some cases, hospitalization may be required for further evaluation and treatment.

Reply Date: 2005/01/19

More Info


Unexplained fever can be a perplexing and concerning symptom, especially when it fluctuates between high and low temperatures, as you've described. Your experience of sudden fever reaching up to 39.5 degrees Celsius, accompanied by body aches, weakness, and occasional near-fainting spells, warrants careful consideration.
Fever is a natural response of the body to infection or illness, and it serves as a defense mechanism against pathogens. The body's normal temperature range is typically around 36.1 to 37.2 degrees Celsius, and anything above this range is generally considered a fever. In your case, the fluctuating temperatures suggest that your body is actively responding to some underlying issue.

Given that you have experienced these symptoms without any accompanying respiratory symptoms like sore throat, runny nose, or cough, it is essential to consider other potential causes of fever. Common causes of unexplained fever can include:
1. Infections: While respiratory infections are common, other infections such as urinary tract infections, gastrointestinal infections, or even more systemic infections like viral or bacterial infections can present with fever and body aches without typical respiratory symptoms.

2. Autoimmune Disorders: Conditions such as lupus or rheumatoid arthritis can cause fever as part of their symptomatology. These disorders often present with systemic symptoms, including fatigue and joint pain.

3. Malignancies: Certain cancers can present with unexplained fevers, particularly lymphomas or leukemias. This is often accompanied by other systemic symptoms like weight loss, night sweats, or fatigue.

4. Medications: Sometimes, medications can induce fever as a side effect. If you have started any new medications recently, this could be a consideration.

5. Other Causes: Conditions such as hyperthyroidism, heat exhaustion, or even stress can lead to fluctuations in body temperature and feelings of weakness.

Since you mentioned that you do not frequently experience colds or flu, and your previous medical evaluations have not yielded a definitive cause for your fevers, it may be prudent to pursue further investigations. Here are some recommendations:
- Blood Tests: A complete blood count (CBC) can help identify signs of infection or inflammation. Additional tests, such as blood cultures, can help identify any underlying infections.

- Imaging Studies: Depending on your symptoms and physical examination findings, imaging studies like X-rays or ultrasounds may be warranted to rule out any hidden infections or abnormalities.

- Referral to a Specialist: If your primary care physician is unable to determine the cause of your fever, a referral to an infectious disease specialist or a rheumatologist may be beneficial for further evaluation.

- Monitoring Symptoms: Keep a detailed log of your symptoms, including temperature readings, any new symptoms that arise, and any potential triggers. This information can be invaluable for your healthcare provider in diagnosing your condition.

In conclusion, while it is reassuring that your fever has responded to treatment, the persistence of fluctuating temperatures and accompanying symptoms suggests that further investigation is warranted. It is essential to communicate openly with your healthcare provider about your concerns and the need for additional testing to ensure that any underlying conditions are identified and appropriately managed. Your health is paramount, and taking proactive steps in understanding your symptoms will lead to better outcomes.

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