the Effects of Premarin and Provera on Menstrual Irregularities

Q: the Effects of Premarin and Provera on Menstrual Irregularities

Dear Qing： Premarin is an estrogen, and Provera is a progestin. <br>The general method of use for addressing endocrine irregularities is as you mentioned in your medical advice, primarily to supplement the hormone levels during the follicular and luteal phases of the menstrual cy

Inquiry about Premarin and Provera?

Hello, I previously experienced irregular menstruation, with bleeding that lasted for a whole month in December of last year, although it was light (somewhat dark brown).
I visited a doctor in mid-December, who diagnosed it as hormonal imbalance.
During that month, I was prescribed [Kylian] for three weeks to help regulate my cycle.
However, I continued to have light bleeding during the treatment.
When I returned for a follow-up in January, coinciding with the end of my [Kylian] course, the doctor mentioned that [Kylian] was ineffective for me since I was still experiencing bleeding.
Consequently, I was prescribed Premarin and Provera.
I was instructed to take Premarin for the first 14 days in the morning and evening, and Provera for the following 14 days, also in the morning and evening, with a two-day overlap.
What effects can I expect from this regimen? My menstruation lasted about three days (from January 13 to January 15).
Now that my period has ended, I started taking Premarin on January 17, and it seems like the bleeding has stopped.
However, after a few days of taking it, I have noticed some dull pain on both sides of my abdomen.
Is this normal? I would like to know if taking these two medications could have any effects on my body.
Are these medications safe? Do they have contraceptive effects? (As the previous medication, [Kylian], did.) Since I am no longer bleeding, should I continue taking them?

Qing, 20~29 year old female. Ask Date: 2005/01/24

Dr. Liao Lingmei reply Pharmacology

Dear Qing: Premarin is an estrogen, and Provera is a progestin.
The general method of use for addressing endocrine irregularities is as you mentioned in your medical advice, primarily to supplement the hormone levels during the follicular and luteal phases of the menstrual cycle.
Whether to continue taking the menstrual regulation medication should be determined by a physician, but it usually requires a few months of treatment.
The side effects of Premarin may include bloating and abdominal pain, but most symptoms are generally mild.

When discussing the effects of Premarin and Provera on the body, it is typically a discussion of the benefits and risks for postmenopausal women.
I believe you are only using them short-term, so many long-term side effects are not relevant here.
Taking low doses of estrogen and progestin can have contraceptive effects; however, the estrogen and progestin content in Premarin and Provera is relatively high, which can lead to more pronounced side effects, making them unsuitable as contraceptive medications, although they may still provide some contraceptive effect.
For treatment-related questions, it is advisable to consult with your physician.
Wishing you health and happiness!

Reply Date: 2005/01/24

More Info

Premarin (conjugated estrogens) and Provera (medroxyprogesterone acetate) are commonly prescribed medications for managing menstrual irregularities, particularly those related to hormonal imbalances. Understanding their effects, potential side effects, and implications for future pregnancy is crucial for anyone considering their use.

Mechanism of Action:
Premarin is a form of estrogen, a hormone that plays a vital role in regulating the menstrual cycle. It helps to rebuild the uterine lining after menstruation and is often used to treat symptoms of menopause or to manage irregular menstrual cycles. Provera, on the other hand, is a synthetic form of progesterone. It helps to stabilize the uterine lining and can prevent excessive growth that can lead to abnormal bleeding. When used together, these medications can effectively regulate the menstrual cycle by mimicking the natural hormonal fluctuations that occur in a typical cycle.

Effects on Menstrual Irregularities:
In your case, the combination of Premarin and Provera is intended to address the irregular bleeding you experienced. The treatment regimen you mentioned—taking Premarin for the first 14 days and Provera for the subsequent 14 days, with a two-day overlap—aims to provide a balanced hormonal environment. This approach can help to normalize your menstrual cycle, reduce abnormal bleeding, and alleviate symptoms associated with hormonal imbalances.

Potential Side Effects:
While many individuals tolerate these medications well, they can cause side effects. Common side effects of Premarin may include nausea, breast tenderness, headaches, and abdominal discomfort. Provera can also lead to similar side effects, including mood changes, weight gain, and bloating. The abdominal discomfort you mentioned could be a result of these medications, especially if you are still adjusting to the hormonal changes they induce. If the discomfort persists or worsens, it would be wise to consult your healthcare provider.

Impact on Future Pregnancy:
Regarding your concerns about future pregnancy, it is essential to discuss this with your healthcare provider. Both Premarin and Provera can influence fertility, but they are often used to correct hormonal imbalances that may be contributing to difficulties in conceiving. If you are planning to become pregnant, your doctor may recommend discontinuing these medications at a certain point to allow your natural hormonal cycle to resume.

Contraceptive Effects:
As for contraceptive effects, while these medications can help regulate the menstrual cycle, they are not primarily intended as contraceptives. However, they may have some contraceptive effects due to the hormonal changes they induce. If you are not planning to conceive immediately, it is crucial to discuss alternative contraceptive methods with your healthcare provider.

Continuation of Treatment:
If you have noticed a reduction in abnormal bleeding, it may be beneficial to continue the treatment as prescribed. However, the decision to continue should always be made in consultation with your healthcare provider, who can assess your specific situation and determine the best course of action.

In summary, Premarin and Provera can be effective in managing menstrual irregularities caused by hormonal imbalances. While they may have side effects, many individuals find them beneficial for regulating their cycles. Always communicate openly with your healthcare provider about any concerns or symptoms you experience during treatment, especially regarding future pregnancy plans.

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