Is My Weight Loss Plan with Nometine Safe and Effective?

Q: Is My Weight Loss Plan with Nometine Safe and Effective?

Hello： Normethermine acts on the neurocytes in the hypothalamic satiety center, inhibiting the reabsorption of serotonin and norepinephrine, which allows the body to experience a feeling of fullness earlier, thereby reducing energy intake. <br>It is important to emphasize that th

Can I take Normetex this way?

Hello Doctor: I have been taking Normetex for six days from March 7 (Tuesday) to March 13 (Sunday).
I have been controlling my daily caloric intake to approximately 800 to 1100 calories, primarily consisting of proteins (e.g., chicken, eggs, shrimp, tofu, milk) and vegetables (e.g., tomatoes, onions, corn, mushrooms), with a slice of whole grain toast for carbohydrates at breakfast.
Additionally, I drink 2500cc of water daily and have a bowel movement once a day.
I also supplement with a multivitamin, B vitamins, and dietary fiber.
As a result, my weight has decreased from 63.4 kg on March 7 to 62.0 kg on March 13, totaling a loss of 1.4 kg.
Could you please help me assess my situation: Is this normal? Am I consuming too few calories? Am I eating too little carbohydrates? If I continue like this for a month, will my metabolic rate decrease too much? I am taking 10 mg for a 28-day supply and I am currently 158 cm tall.

Ling, 20~29 year old female. Ask Date: 2005/03/13

Dr. Hou Fangmin reply Pharmacology

Hello: Normethermine acts on the neurocytes in the hypothalamic satiety center, inhibiting the reabsorption of serotonin and norepinephrine, which allows the body to experience a feeling of fullness earlier, thereby reducing energy intake.
It is important to emphasize that the sensation of fullness is different from appetite suppression; it does not eliminate the desire to eat but rather advances the timing of when one feels full (resulting in smaller meal sizes).
However, the efficacy of this medication varies from person to person due to individual differences in physiology, so not everyone will achieve the same appetite-suppressing effects from Normethermine.
In the first month of taking Normethermine, an average weight loss of at least two kilograms can be expected, and after three to six months of use, 94% of patients may lose more than 5% of their body weight.
However, Normethermine also has side effects, primarily dry mouth, constipation, or insomnia.
Increasing water intake and consuming fiber-rich foods can help alleviate these issues.
Regarding insomnia, since Normethermine acts on the central nervous system, it is not recommended for patients with mental health disorders.
Additionally, it is not advisable for individuals under 18, over 65, pregnant or breastfeeding women, women planning to become pregnant, and those with heart failure, arrhythmias, or significant blood pressure fluctuations to take Normethermine.
It should be used in conjunction with dietary control and exercise.

According to international reports, taking 10 mg of Reductil can lead to approximately 5% weight loss over a year, while a domestic report indicates an average weight loss of about 3.63 kilograms over five months.
I think your situation is manageable, but remember to exercise more; otherwise, it will be easy to regain weight once you stop the medication.
I hope this response is helpful.
Bye.

Reply Date: 2005/03/13

More Info

Your weight loss plan using Nometine (also known as Sibutramine) raises several important considerations regarding safety, effectiveness, and nutritional balance. First, let’s analyze your current regimen.

You mentioned that you have been consuming between 800 to 1100 calories daily, primarily from protein sources (like chicken, eggs, shrimp, tofu, and milk) and vegetables (such as tomatoes, onions, corn, and mushrooms), with a small amount of carbohydrates from a slice of whole grain toast at breakfast. This dietary approach, while rich in protein and fiber, is significantly low in calories. For someone of your height (158 cm) and current weight (62 kg), the recommended caloric intake for weight maintenance is generally higher than what you are consuming. A drastic reduction in caloric intake can lead to nutritional deficiencies and may negatively impact your metabolism over time.

The weight loss you have experienced (1.4 kg in six days) is quite rapid. While initial weight loss can be encouraging, it is essential to understand that such a steep decline may not be sustainable and could lead to muscle loss rather than fat loss. Rapid weight loss can also trigger a metabolic slowdown, where your body adapts to the lower caloric intake by reducing its metabolic rate, making it harder to lose weight in the future.

Regarding your concern about carbohydrate intake, while it is beneficial to limit refined carbohydrates and sugars, completely minimizing them can lead to energy deficits and may affect your overall health. Carbohydrates are an essential macronutrient that provides energy, especially for physical activity. It is advisable to include healthy sources of carbohydrates, such as whole grains, fruits, and legumes, in moderation.

As for the use of Nometine, it is designed to help suppress appetite and promote a feeling of fullness, which can assist in weight loss. However, it is crucial to be aware of its potential side effects, including dry mouth, constipation, and insomnia. Additionally, Nometine is not recommended for individuals with certain health conditions, including those with a history of cardiovascular issues, and it should be used under medical supervision.

If you continue with this low-calorie diet and Nometine for an extended period, there is a risk that your metabolic rate may decrease, leading to a plateau in weight loss or even weight regain once you stop the medication. It is essential to incorporate physical activity into your routine, as exercise can help maintain muscle mass and support metabolic health.

In summary, while your weight loss plan may yield short-term results, it is crucial to ensure that it is safe and sustainable in the long run. I recommend consulting with a healthcare professional or a registered dietitian to evaluate your dietary plan, caloric intake, and the use of Nometine. They can help you create a balanced approach that promotes healthy weight loss while ensuring you meet your nutritional needs and maintain a healthy metabolism.

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