the Effects of Nomitine: Weight Loss and Body Fat Concerns

The medication Nometine?

I recently started using weight loss medication prescribed by a pharmacist, which is divided into morning and evening doses.
The morning formula includes: Nometine + fish oil + ...
(I am not sure about the other ingredients), and the evening formula includes: fish oil + liver extract + ...
(I am not sure about the other ingredients).
I drink over 3500cc of water daily, and my appetite has decreased.
On the first day of taking the medication, my waist circumference noticeably reduced by one inch, and about 3 to 4 days later, my abdominal measurements also started to decrease significantly, along with a weight loss.
However, I am wondering why my body fat percentage seems to remain the same, and at times even shows an increasing trend (I measure my weight and body fat percentage at almost the same time every day).
The pharmacist mentioned that this is normal because my metabolism is poor, and body fat will only start to decrease after a week.

(1) Is this true? Or am I just losing water weight?
(2) Is losing weight this quickly normal?
(3) Currently, I have not experienced any breast reduction; is it possible in the future?
(4) Are there any dietary or other considerations I should be aware of?
(5) If I stop taking the medication after one month, will I regain weight? I have heard that Nometine needs to be taken continuously for three months to be truly effective.

(6) How can I maintain my weight loss after achieving my goal?
P.S.
I have a bowel movement once a day, which is loose (I have been on the medication for about a week).
My height is 156 cm, weight is 55.8 kg, and body fat percentage is 33%.

Tang糖, 10~19 year old female. Ask Date: 2004/06/26

Dr. Hou Fangmin reply Pharmacology

Naltrexone acts on the hypothalamic satiety center, inhibiting the duration of neurotransmitter action, which leads to a feeling of fullness and a decreased appetite for further eating, thereby reducing caloric intake.
Side effects may include dry mouth, insomnia, and constipation.
If one eats multiple times a day, the weight loss effect may diminish.
Relying solely on medication for weight loss without accompanying dietary changes and exercise will significantly reduce effectiveness.
Moreover, medications must be approved by the Ministry of Health and Welfare for safety.
It is recommended that you use medications only under the prescription of a specialist and avoid purchasing unverified drugs from outside sources, as this may ultimately hinder weight loss and harm your health.

While Naltrexone does not raise blood pressure as easily as PPA, it is still not advisable for individuals with poorly controlled blood pressure.
Blood pressure and heart rate should be monitored during treatment.
Individuals with arrhythmias, impaired liver or kidney function, hyperthyroidism, or cardiovascular diseases should also avoid Naltrexone.
Naltrexone is a prescription medication with several contraindications; for instance, it should not be used in conjunction with PPA or certain psychiatric medications, so it must be used under the guidance of a physician and pharmacist.
Your concerns should focus on maintaining a balanced diet and increasing physical activity.
Stopping the medication after one month may lead to weight regain, as Naltrexone typically requires 3-5 months of use for better maintenance of weight loss.
I suggest visiting a clinic for weight management, where a physician can order blood tests to assess your health status and adjust your dosage accordingly.
To maintain your weight loss, regular exercise is essential.

Reply Date: 2004/06/26

More Info

When considering the use of weight loss medications like Nomitine, it's essential to understand how they affect your body, particularly in terms of weight loss, body fat percentage, and overall metabolic health. Based on your experience and questions, let's break down the various aspects of your situation.

1. Weight Loss and Body Composition: It's common for individuals to experience a rapid decrease in weight when starting a weight loss medication, especially if they are also making dietary changes. The initial weight loss can often be attributed to water loss, particularly if you have reduced your caloric intake significantly. This is because your body may shed excess water weight as it adjusts to a new diet. However, fat loss typically takes longer to manifest. The pharmacist's comment about your metabolism being slow may be valid; it can take time for your body to adjust and start burning fat effectively.
2. Rapid Weight Loss: Losing weight quickly can be concerning. While some initial weight loss is normal, especially in the first week, a sustainable rate of weight loss is generally considered to be about 1-2 pounds (approximately 0.5-1 kg) per week. Rapid weight loss can sometimes lead to muscle loss, nutritional deficiencies, and other health issues. It's crucial to ensure that your diet remains balanced and that you're not overly restricting calories.

3. Breast Size Changes: Weight loss can lead to changes in breast size, as breasts are composed of fatty tissue. While you may not have noticed any changes yet, it is possible that as you continue to lose weight, your breast size may decrease. This is a common occurrence for many individuals during weight loss.

4. Dietary Considerations: To support your weight loss efforts while using Nomitine, focus on a balanced diet rich in whole foods. Incorporate lean proteins, healthy fats, and plenty of fruits and vegetables. Avoid highly processed foods and sugars, as these can hinder your progress. Additionally, ensure you're consuming enough fiber to support digestive health, especially since you've mentioned having loose stools.

5. Stopping the Medication: If you decide to stop taking Nomitine after a month, it's essential to be mindful of potential weight regain. Many individuals experience weight rebound after discontinuing weight loss medications if they do not maintain healthy lifestyle changes. To mitigate this, focus on establishing a sustainable diet and exercise routine that you can maintain long-term. Gradually reducing your caloric intake rather than stopping abruptly can also help.

6. Maintaining Weight Loss: After achieving your weight loss goals, maintaining your new weight will require ongoing effort. This includes regular physical activity, mindful eating, and possibly continuing to track your food intake and exercise. Consider setting realistic goals and finding a support system, whether through friends, family, or weight loss groups, to help keep you accountable.

In summary, while your initial weight loss may be encouraging, it's essential to approach your weight loss journey holistically. Monitor your body’s responses, maintain a balanced diet, and engage in regular physical activity. If you have concerns about your body fat percentage or any side effects from the medication, consulting with a healthcare professional is advisable to ensure you're on the right track and to address any potential health issues.

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