Side Effects of Psychiatric Medications: A Guide

Psychiatric medications

Dear Pharmacist,
I would like to ask if taking Efexor and Lorazepam could cause constipation as I have been experiencing it.
Additionally, does the injection of Ativan have significant side effects? Is it typically administered in severe cases? Furthermore, I accidentally swallowed 7 Stilnox and 2 Lorazepam at once.
I did see a doctor, but it was a while ago, and I only received IV fluids without any other treatment.
Could this have caused serious side effects or harm to my body? Is there any way to minimize the damage? I apologize for asking so many questions.
Thank you, Pharmacist Liu.

mimi mei mei, 10~19 year old female. Ask Date: 2005/04/13

Dr. Liu Huiya reply Pharmacology

Dear Mini,
1.
Among the two medications, Efexor and lorazepam, only Efexor has been reported to have gastrointestinal side effects during studies, with a nausea incidence rate of 30-35% (compared to 9-12% for placebo), followed by constipation at 8-10% (compared to 4-5% for placebo).
Since you have been experiencing constipation, have you considered other potential causes? Besides medication, factors such as lack of exercise (insufficient abdominal muscle tone), dieting (insufficient stool volume), inadequate fluid and fiber intake, and irregular routines could also contribute to constipation.
If you have ruled out these causes and the issue persists, you may inform your physician about the possibility of short-term use of a stool softener.
2.
Ativan injection contains lorazepam, which is a fast-acting and short-duration medication used to quickly address anxiety and help patients regain emotional stability.
Common side effects of this medication include mild dizziness, lightheadedness, and feelings of weakness, but these are usually within an acceptable range for users.
This medication is not only for severe cases; it is administered at the physician's discretion when they determine that the patient requires lorazepam injection.
3.
Taking Stilnox and lorazepam at the dosage you mentioned may lead to more pronounced side effects compared to the generally recommended doses, such as drowsiness, nausea, vomiting, slurred speech, and unsteady gait.
Since you sought medical attention at that time and both medications are not long-acting, they will gradually be eliminated from your body over time.
If you are currently not experiencing any significant discomfort, there is no need to worry excessively.
Given your regular use of lorazepam, it is advisable to increase your intake of vitamin C-rich foods or supplements.
To improve sleep issues, you might also consider learning relaxation techniques, which could be very beneficial for you.
Thank you for your letter, and I wish you peace and safety!

Reply Date: 2005/04/13

More Info

Understanding the side effects of psychiatric medications is crucial for anyone undergoing treatment for mental health conditions. The medications you mentioned, Efexor (Venlafaxine) and Lorazepam (Ativan), are commonly prescribed but can have various side effects, including gastrointestinal issues like constipation.

Side Effects of Efexor (Venlafaxine)
Venlafaxine is a serotonin-norepinephrine reuptake inhibitor (SNRI) primarily used to treat depression and anxiety disorders. While it can be effective in managing symptoms, it is known to cause several side effects. One of the more common gastrointestinal side effects is constipation. This occurs because SNRIs can affect the autonomic nervous system, which regulates bowel movements. If you are experiencing persistent constipation, it is essential to discuss this with your healthcare provider. They may recommend dietary changes, increased hydration, or even a mild laxative to help alleviate this issue.

Side Effects of Lorazepam (Ativan)
Lorazepam is a benzodiazepine used to treat anxiety disorders, insomnia, and other conditions. While it can be effective for short-term relief, it also has potential side effects. Common side effects include drowsiness, dizziness, and confusion. In some cases, it can lead to dependence, especially if used for an extended period. Lorazepam can also cause gastrointestinal issues, including constipation, although this is less common than with Venlafaxine.

Concerns About Ativan Injection
The injectable form of Lorazepam (Ativan) is typically used in more severe cases, such as acute anxiety or agitation. While it can be effective, it does carry risks, especially if administered in a hospital setting. Side effects can include sedation, respiratory depression, and hypotension. It is crucial to monitor patients closely after administration to manage any adverse effects promptly.

Overdose Concerns
Regarding your experience with accidentally taking seven Stilnox (Zolpidem) and two Lorazepam, this is a serious situation. Both medications are central nervous system depressants, and taking them in excessive amounts can lead to significant side effects, including severe sedation, respiratory depression, and even coma. The fact that you were monitored and received IV fluids is a positive step, as it indicates that medical professionals were aware of the potential risks and took action to mitigate them.

If you are concerned about long-term effects from this incident, it is essential to follow up with your healthcare provider. They may recommend monitoring your liver function and overall health to ensure no lasting damage occurred.

Minimizing Harm
To minimize potential harm from medications, consider the following strategies:
1. Regular Communication with Your Healthcare Provider: Always keep an open line of communication with your doctor or pharmacist about any side effects you experience. They can adjust your medication or suggest alternatives.

2. Medication Management: Use a pill organizer to help manage your medications and avoid accidental overdoses.
3. Lifestyle Modifications: Incorporate a balanced diet, regular exercise, and adequate hydration to help mitigate some side effects, such as constipation.

4. Avoid Alcohol and Other CNS Depressants: Mixing these substances with your medications can exacerbate side effects and increase the risk of overdose.

5. Educate Yourself: Understanding your medications and their potential side effects can empower you to manage your treatment better.

In conclusion, while medications like Efexor and Lorazepam can be beneficial for managing mental health conditions, they come with risks that require careful monitoring and management. Always consult with your healthcare provider regarding any concerns or side effects you experience, and never hesitate to seek help if you feel overwhelmed by your treatment plan.

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