Post-Inflammatory Pain: Is It Related to Medication? - Urology

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Hello Doctor: A while ago, I had a bladder infection, which escalated to pelvic inflammatory disease.
I consulted a gynecologist who prescribed anti-inflammatory medication.
Since I had experienced this twice before, I have taken quite a bit of medication, and I just finished the course on December 11.
However, on December 14 in the afternoon, I started feeling pain on both sides of my abdomen, especially on the left side, but it is not severe enough to be described as sharp pain (I suspect it might be related to my kidney).
I would like to ask the doctor if this could be related to the anti-inflammatory medication I took.
What consequences could this cause?

Ru, 20~29 year old female. Ask Date: 2005/12/14

Dr. Lin Hexing reply Urology


Hello, bladder inflammation does not typically lead to pelvic inflammatory disease unless it is very severe and results in an inability to urinate, causing the bladder to become purulent.
In such cases, the infection source could potentially penetrate the bladder wall and infect the pelvic cavity; otherwise, the pathways of the two areas are different.
If you still experience symptoms of bladder inflammation (such as frequent urination, burning sensation during urination, lower abdominal pain, small urine output each time, or even difficulty urinating or lower back pain), further urine tests and treatment are necessary.
Of course, the issue of lower back pain you mentioned is unrelated to taking anti-inflammatory medication.
If you still have concerns, further examination is required.

Reply Date: 2005/12/14

More Info


Post-inflammatory pain can be a complex issue, especially after experiencing an infection such as a bladder or pelvic inflammatory disease. It is important to understand the relationship between the medications you have taken and the pain you are currently experiencing.

When you take anti-inflammatory medications, they are designed to reduce inflammation and alleviate pain. Common medications prescribed for such conditions include non-steroidal anti-inflammatory drugs (NSAIDs) like ibuprofen, naproxen, or even stronger prescription medications. While these medications can be effective in managing pain and inflammation, they can also have side effects, particularly when used over an extended period or in high doses.

In your case, the pain you are experiencing on the left side of your abdomen could potentially be related to several factors. First, it is essential to consider that post-inflammatory pain can occur as the body heals from an infection. The tissues in the pelvic area may still be sensitive or inflamed, leading to discomfort even after the infection has resolved. This type of pain is often referred to as "post-inflammatory hyperalgesia," where the nervous system becomes more sensitive following an inflammatory event.

Regarding the medications you have taken, if they are NSAIDs, they can sometimes lead to gastrointestinal issues, kidney problems, or other side effects, especially if taken inappropriately or without proper medical supervision. For instance, NSAIDs can cause irritation of the stomach lining, leading to gastritis or ulcers, and they can also affect kidney function, particularly in individuals with pre-existing kidney issues or dehydration.

If you are experiencing pain that feels like it is coming from the kidney area, it is crucial to monitor for other symptoms such as changes in urination, fever, or any signs of infection. While it is possible that the pain is related to the medications, it could also be a result of residual inflammation or even a new issue that needs to be addressed.

Here are some recommendations:
1. Consult Your Doctor: Given your history of bladder and pelvic inflammatory disease, it is essential to follow up with your healthcare provider. They may want to perform a physical examination or imaging studies to rule out any complications.

2. Medication Review: Discuss the medications you have been taking with your doctor. They can help determine if any of them may be contributing to your current symptoms and whether adjustments are necessary.

3. Hydration: Ensure you are well-hydrated, as dehydration can exacerbate kidney-related pain and increase the risk of kidney issues when taking NSAIDs.

4. Pain Management: If the pain persists, your doctor may recommend alternative pain management strategies that are less likely to cause side effects, such as acetaminophen or topical analgesics.

5. Monitor Symptoms: Keep track of your symptoms, including the intensity and duration of the pain, and any other accompanying symptoms. This information can be valuable for your healthcare provider in diagnosing the issue.

In summary, while post-inflammatory pain can be a normal part of the recovery process, it is essential to differentiate it from potential medication-related side effects or complications. Always consult with your healthcare provider for personalized advice and treatment options tailored to your specific situation.

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