Elevated Liver Enzymes and Sleep Issues: What You Need to Know - Gastroenterology and Hepatology

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Liver issues consultation?


Hello Doctor: I had tests for GOT and GPT at the end of last year.
My GOT was 38.8 U/L and my GPT was 61.22 U/L, both of which are higher than the normal values.
Does this indicate inflammation of the liver? Additionally, for the past few months, I have been experiencing slight stabbing pain in the area on the right side of my waist (where the liver is located), and I have also noticed a yellowing of the whites of my eyes.
What could be the most likely cause of these symptoms? Furthermore, I have frequently stayed up late over the past year (usually going to bed around 2-3 AM), and recently, even when I try to sleep earlier (around 11 PM to midnight), I often toss and turn and have racing thoughts that prevent me from falling asleep (I’m not sure if this is what is referred to as restlessness).
Otherwise, I only manage to fall asleep around 2-3 AM.
Could this be related to liver issues, or is it more likely due to my sleep habits over the past year, which are causing me to have difficulty sleeping when I try to go to bed earlier? Could you please provide some clarification? Thank you!

Xiao Xiao Lin, 20~29 year old female. Ask Date: 2006/05/12

Dr. Lin Minghui reply Gastroenterology and Hepatology


Hello: 1.
Abnormal levels of GOT and GPT, ranging from 1 to 2 times the normal values, indicate liver cell damage, although not significantly elevated.
It is important to investigate the underlying causes, which may include viral hepatitis (types B and C), medications, alcohol consumption, metabolic diseases, autoimmune diseases, and fatty liver disease.
2.
If the sclera appears yellow, it is important to consider the possibility of jaundice.
Potential causes of jaundice include hepatitis, cirrhosis, liver cancer, or biliary tract diseases; it is advisable to consult a physician for examination.
3.
There are many causes of insomnia, and excessive fatigue can lead to worsening liver function.
Sincerely, Dr.
Lin Ming-Hui, Internal Medicine.

Reply Date: 2006/05/12

More Info


Elevated liver enzymes, specifically GOT (AST) and GPT (ALT), can indeed indicate liver inflammation or damage. The normal ranges for these enzymes can vary, but generally, elevated levels suggest that the liver is under stress or has sustained some form of injury. In your case, with GOT at 38.8 U/L and GPT at 61.22 U/L, both values are above the normal limits, which could suggest liver inflammation or other liver-related issues.

The symptoms you describe, such as the mild stabbing pain in the right side of your abdomen (where the liver is located) and the yellowing of the whites of your eyes (jaundice), are concerning. Jaundice typically indicates that there is an accumulation of bilirubin in the blood, which can occur due to liver dysfunction. This could be due to a variety of reasons, including viral hepatitis, fatty liver disease, alcohol-related liver disease, or other liver conditions.

Your history of frequent late nights and poor sleep quality may also contribute to your liver issues. Chronic sleep deprivation can lead to a range of health problems, including metabolic syndrome, which is associated with liver disease. The liver plays a crucial role in detoxification and metabolism, and insufficient sleep can impair these functions, potentially exacerbating any underlying liver issues.

To address your concerns, it is essential to consult a healthcare professional, preferably a hepatologist or a gastroenterologist, who can perform a thorough evaluation. This may include additional blood tests to assess liver function, imaging studies like an ultrasound to visualize the liver, and possibly a liver biopsy if necessary. Understanding the underlying cause of your elevated liver enzymes is crucial for appropriate treatment.

In terms of improving your liver health and sleep quality, here are several recommendations:
1. Sleep Hygiene: Establish a regular sleep schedule by going to bed and waking up at the same time every day. Create a relaxing bedtime routine to signal to your body that it’s time to wind down. Limit screen time before bed, as blue light can interfere with melatonin production.

2. Dietary Changes: Adopt a liver-friendly diet rich in fruits, vegetables, whole grains, and lean proteins. Avoid alcohol, processed foods, and excessive sugar, as these can contribute to liver stress.

3. Hydration: Drink plenty of water throughout the day to help your liver function optimally and to flush out toxins.

4. Exercise: Regular physical activity can improve overall health and may help reduce liver fat, especially if you are overweight. Aim for at least 150 minutes of moderate aerobic activity each week.

5. Stress Management: Since you mentioned feeling anxious and having racing thoughts at night, consider incorporating stress-reducing techniques such as mindfulness, meditation, or yoga into your daily routine.

6. Avoid Self-Medication: Be cautious with over-the-counter medications and supplements, as some can be harmful to the liver, especially when taken in excess or without medical supervision.

7. Regular Check-ups: Keep up with regular medical appointments to monitor your liver function and overall health. This will help catch any potential issues early.

In conclusion, while your sleep habits may be contributing to your current state, the elevated liver enzymes and symptoms you are experiencing warrant further investigation. Prioritizing your health by seeking medical advice and making lifestyle changes can significantly improve your liver function and overall well-being.

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