Does Long-Term Low-Dose Aspirin Cause Ear Toxicity and Hearing Loss? - Otolaryngology

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Long-term use of low-dose aspirin (100 mg daily) is generally considered safe for most individuals and is commonly prescribed for its cardiovascular benefits, such as reducing the risk of heart attacks and strokes. However, concerns about potential side effects, including ototoxicity (ear toxicity) and hearing loss, are valid and warrant discussion.

Aspirin is known to have a dose-dependent relationship with ototoxicity. This means that higher doses of aspirin are more likely to cause adverse effects on hearing. In clinical settings, doses of aspirin that exceed 300 mg per day have been associated with tinnitus (ringing in the ears) and hearing loss. The mechanism behind this is thought to involve the drug's effect on the cochlea, the auditory portion of the inner ear, where it can disrupt the normal function of hair cells responsible for hearing.

For individuals taking low doses, such as 100 mg daily, the risk of developing ototoxicity is significantly lower. Most studies suggest that this level of aspirin does not typically lead to hearing loss or tinnitus. However, individual responses can vary, and some people may experience sensitivity to even low doses. Factors such as pre-existing ear conditions, concurrent use of other ototoxic medications, or personal health history can influence the risk.

If a person were to take a single high dose of aspirin, the threshold for ototoxicity is not precisely defined, but doses above 300 mg are generally considered to carry a higher risk. In some cases, doses as high as 600 mg or more have been reported to cause temporary hearing issues. It is essential to note that the risk of hearing loss from high doses is usually reversible upon discontinuation of the medication, but this is not guaranteed for everyone.

In summary, long-term use of low-dose aspirin (100 mg) is unlikely to cause ear toxicity or hearing loss in most individuals. However, if you have concerns about your hearing or experience symptoms such as tinnitus or hearing changes while taking aspirin, it is crucial to consult with a healthcare professional. They may recommend hearing tests or adjustments to your medication regimen based on your specific health needs.

Additionally, if you are taking other medications or have underlying health conditions, it is essential to discuss these with your doctor, as they can provide personalized advice and monitor for any potential interactions or side effects. Regular check-ups and open communication with your healthcare provider can help ensure that your treatment plan remains safe and effective.