Can G6PD Patients Safely Use Fushuguan Capsules?

excuse me?

Is this medication safe for patients with G6PD deficiency? The medication is Fushuganlong capsules, which contain the following ingredients: Acetaminophen 300mg, Chlorpheniramine Maleate 2.5mg, Dextromethorphan Hydrobromide 15mg, dl-Methylephedrine Hydrochloride 10mg, Potassium Guaiacol Sulfonate 60mg, Caffeine Anhydrous 30mg, Thiamine Hydrochloride 8mg, and Riboflavin 4mg.
This medication is registered under the number 026818 by the Ministry of Health.
Are there any other side effects associated with this medication? A family medicine physician has advised against its use, so I am unsure if it is safe to take.

Lai, 10~19 year old female. Ask Date: 2006/10/20

Dr. Su Yuwen reply Pharmacology

Dear Mr.
Lai,
1.
Fusukanron Capsules are a comprehensive cold treatment medication.
Its side effects include:
1.
Drowsiness, dry mouth, fatigue, blurred vision, confusion, difficulty urinating, and increased heart rate.
2.
Occasional allergic reactions.
3.
Rare side effects when used at recommended dosages.
4.
Long-term use of excessive doses may lead to hepatotoxicity.
2.
Regarding medication issues for patients with G6PD deficiency:
Patients with G6PD deficiency should avoid the following medications:
1.
Antimalarial drugs, such as Primaquine, Pamaquine, and Plasmoquine.
2.
Sulfonamide antibiotics, such as Sulfanilamide, Sulfapyridine, Sulfisoxazole, Sulfacetamide, and Salicylazosulfapyridine.
3.
Antipyretic and analgesic medications, such as Aspirin, Acetanilide, Phenacetin, Antipyrine, Aminopyrine, and P-aminosalicylic acid.
4.
Certain antibiotics or disinfectants, such as nitrofurantoin, furazolidone, and furaltadone.
5.
Other chemicals, such as naphthalene, gentian violet, methylene blue, phenylhydrazine, acetylphenylhydrazine, probenecid (a uricosuric agent), and sulfoxone.
3.
Recommendations for patients:
1.
If you are ill and see a doctor, be sure to inform the physician in advance so they can avoid prescribing medications that may have adverse effects.
2.
When purchasing medications at a pharmacy, it is best to seek a pharmacy with qualified pharmacists and to communicate your condition clearly.
3.
When buying personal care products, over-the-counter medications, or health supplements, be cautious and inquire with the store staff.
If in doubt, it is best not to purchase.
I hope this information meets your needs.
Wishing you peace and health.

Reply Date: 2006/10/20

More Info

When considering whether G6PD (Glucose-6-Phosphate Dehydrogenase) deficiency patients can safely use Fushuguan Capsules, it is essential to analyze the components of the medication and the known contraindications associated with G6PD deficiency.

Fushuguan Capsules contain the following active ingredients:
- Acetaminophen (300 mg)
- Chlorpheniramine Maleate (2.5 mg)
- Dextromethorphan Hydrobromide (15 mg)
- dl-Methylephedrine Hydrochloride (10 mg)
- Potassium Guaiacol Sulfonate (60 mg)
- Caffeine Anhydrous (30 mg)
- Thiamine Hydrochloride (8 mg)
- Riboflavin (4 mg)

G6PD Deficiency and Medication Safety
G6PD deficiency is a genetic condition that affects the red blood cells' ability to handle oxidative stress. Patients with this condition must avoid certain medications and substances that can trigger hemolytic anemia, a condition where red blood cells are destroyed faster than they can be made. Common medications to avoid include:
- Certain antimalarials (e.g., Primaquine)
- Sulfonamide antibiotics
- Aspirin and other non-steroidal anti-inflammatory drugs (NSAIDs)
- Some antibiotics (e.g., nitrofurantoin)
- Certain food items (e.g., fava beans)

Analysis of Fushuguan Capsules
1. Acetaminophen: Generally considered safe for G6PD patients. It does not have the same hemolytic risk as aspirin or other NSAIDs.

2. Chlorpheniramine Maleate: An antihistamine that is not known to pose risks for G6PD deficiency.

3. Dextromethorphan: A common cough suppressant that is also considered safe for G6PD patients.

4. dl-Methylephedrine Hydrochloride: A decongestant that does not have known contraindications for G6PD deficiency.

5. Potassium Guaiacol Sulfonate: This is an expectorant and is not known to be harmful to G6PD patients.

6. Caffeine Anhydrous: Generally safe for G6PD patients, though excessive caffeine can lead to other issues like increased heart rate or anxiety.

7. Thiamine Hydrochloride and Riboflavin: Both are vitamins and are safe for G6PD patients.

Conclusion and Recommendations
Based on the components of Fushuguan Capsules, it appears that this medication does not contain any ingredients that are contraindicated for G6PD deficiency. Therefore, it is likely safe for G6PD patients to use Fushuguan Capsules. However, it is crucial to consider individual patient circumstances, including any other medications they may be taking and their overall health condition.

Additional Considerations
- Consultation with Healthcare Providers: It is always advisable for G6PD patients to consult with their healthcare provider before starting any new medication, including over-the-counter products. This ensures that all potential interactions and contraindications are considered.

- Monitoring for Side Effects: While the ingredients in Fushuguan Capsules are generally safe, patients should be aware of potential side effects such as drowsiness, dry mouth, or increased heart rate, which can occur with some of the components.

- Avoiding Self-Medication: G6PD patients should avoid self-medicating and should always inform their healthcare providers about their condition to ensure safe prescribing practices.

In summary, while Fushuguan Capsules do not contain known harmful ingredients for G6PD patients, individual assessment and professional medical advice are paramount for safe medication use.

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