Post-Injection Complications: A Case Study - Internal Medicine

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After receiving the injection?


On February 1st, around 11 AM, I accompanied a friend to a pediatric clinic for a consultation.
Her symptoms included muscle pain, headache, and neck stiffness.
The doctor diagnosed her with what seemed to be influenza and administered an anti-inflammatory injection.
I waited outside the injection room, and after the injection, my friend came out and asked me to help massage her because she was feeling very sore.
At that time, she was standing, but as I massaged her, her body became increasingly limp.
I quickly helped her sit down and called for the doctor loudly.
My friend appeared to be on the verge of fainting, repeatedly saying she felt unwell all over, with severe pain in her head and neck, and experiencing numbness throughout her body.
We then called an ambulance to take her to a major hospital's emergency department.
On February 2nd, around noon, I learned that she had pulmonary edema and unstable blood pressure.
I would like to ask if an injection accidentally administered into a blood vessel could cause pulmonary edema.
Is my friend's condition due to an allergy to the injection, an issue with the nurse administering the injection, or could it be a case of vasovagal syncope? This was her first time receiving an injection at that clinic!

Pengyou, 20~29 year old female. Ask Date: 2007/02/03

Dr. Wang Fangli reply Internal Medicine


The information you provided is insufficient for making a diagnosis or assessment.
The hospital that provided your emergency care should have the most comprehensive data.
If you have concerns about the treatment from the first clinic, it is advisable to consult with a physician at the emergency hospital for their opinion.

Reply Date: 2007/02/03

More Info


In the case you presented, your friend's experience following the injection raises several important considerations regarding post-injection complications, particularly in pediatric patients. The symptoms she exhibited—muscle pain, headache, neck pain, and subsequent faintness—could be attributed to a variety of factors, including the medication administered, the injection technique, and her individual health status.

Firstly, it is essential to understand that injections, especially those involving medications like anti-inflammatory agents, can lead to various side effects. In your friend's case, the immediate reaction of feeling faint and experiencing widespread discomfort could suggest an adverse reaction to the medication itself or a response to the injection process.
Potential Causes of Symptoms:
1. Allergic Reaction: If your friend has a history of allergies, it's possible that she experienced an allergic reaction to the medication injected. Allergic reactions can range from mild to severe and may include symptoms such as hives, swelling, difficulty breathing, and in some cases, anaphylaxis, which can lead to fainting or shock.

2. Injection Technique: The technique used by the healthcare provider during the injection is crucial. If the injection was inadvertently administered into a blood vessel rather than the intended muscle or subcutaneous tissue, it could lead to systemic effects, including changes in blood pressure and heart rate, which might explain her symptoms of feeling faint and unwell.

3. Vasovagal Response: This is a common reaction to medical procedures, particularly injections. It occurs when the body overreacts to certain triggers, such as pain or anxiety, leading to a sudden drop in heart rate and blood pressure, which can cause fainting. This could explain why your friend felt increasingly weak and needed assistance.

4. Medication Side Effects: The specific medication injected can also have side effects that may contribute to her symptoms. For instance, some anti-inflammatory medications can cause gastrointestinal discomfort, dizziness, or even fluid retention, which could lead to pulmonary complications if severe.

Pulmonary Edema and Blood Pressure Instability:
Regarding your question about whether an injection could lead to pulmonary edema, it is generally unlikely that a properly administered injection would directly cause this condition. However, if the medication entered the bloodstream inappropriately or if your friend had an underlying condition (such as heart disease or fluid overload), it could potentially contribute to pulmonary complications. Blood pressure instability could also arise from a severe allergic reaction or a vasovagal response.

Next Steps:
Given your friend's serious symptoms, it is crucial that she receives thorough medical evaluation and monitoring. The healthcare team should assess her for any signs of an allergic reaction, review her medical history for any pre-existing conditions, and monitor her vital signs closely.
In conclusion, while injections are generally safe, they can lead to complications, particularly in sensitive populations such as children. It is essential for healthcare providers to be aware of the patient's medical history, potential allergies, and the correct technique for administering injections to minimize risks. If your friend has a known allergy or sensitivity to certain medications, this should be communicated clearly to all healthcare providers in the future to prevent similar incidents.

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