Can I Switch My Child's Vaccine from Four-in-One to Six-in-One? - Pediatrics

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Can the four-in-one vaccine be replaced with the six-in-one vaccine?


Hello Dr.
Pei,
My daughter is currently six months old.
She received the four-in-one vaccine at two and four months of age.
For her next vaccination, can we switch to the five-in-one or six-in-one vaccine? Please provide your advice.
Thank you!

Xiao Qi, 30~39 year old female. Ask Date: 2007/03/02

Dr. Pei Rensheng reply Pediatrics


Hello! Your daughter is currently six months old and has received the pentavalent vaccine at two and four months of age.
For this vaccination (at six months) or the next one (at eighteen months), you can switch to the hexavalent vaccine.
However, if your third dose is the hexavalent vaccine, please note that it includes the pentavalent vaccine plus the hepatitis B vaccine (which reduces the number of injections for your baby).
The dosage of the hepatitis B vaccine in the hexavalent formulation is only half of the standard free hepatitis B vaccine dosage.
Therefore, if the third dose is the hexavalent vaccine, you should also administer the hexavalent vaccine at the next appointment (at eighteen months).
Generally, the hexavalent vaccine is about $25 more expensive than the pentavalent vaccine; the current price at Taoyuan City Hospital is $1840 compared to $1815, for your reference.
Thank you! Wishing you health and happiness.
Sincerely, Pei Ren-Sheng.

Reply Date: 2007/03/02

More Info


When it comes to pediatric vaccinations, particularly regarding the switch from a four-in-one vaccine to a five-in-one or six-in-one vaccine, it is essential to understand the implications and recommendations from health authorities. In your case, since your daughter has already received the four-in-one vaccine at two and four months, you are considering whether it is appropriate to switch to a five-in-one or six-in-one vaccine for her next dose.

Based on the information provided and current vaccination guidelines, it is generally acceptable to switch between different combination vaccines, provided that the vaccines in question cover the same diseases and are approved for use in your child's age group. The four-in-one vaccine typically includes DTaP (diphtheria, tetanus, and pertussis), IPV (inactivated poliovirus), and Hib (Haemophilus influenzae type b). The five-in-one vaccine adds hepatitis B, while the six-in-one vaccine includes all of the above plus an additional component, which may vary depending on the manufacturer.

In situations where there has been a shortage of specific vaccines, health authorities have recommended that parents can switch to a different vaccine combination as long as the new vaccine covers the necessary diseases. This flexibility is crucial in ensuring that children remain protected against preventable diseases, especially during critical vaccination windows.
For your daughter, since she has already received the four-in-one vaccine, switching to a five-in-one or six-in-one vaccine for her next dose should not pose any significant risks. The immune system is capable of handling different formulations, and the vaccines are designed to work effectively even if a child has received different combinations in previous doses.
However, it is essential to consult with your pediatrician or healthcare provider before making any changes to your child's vaccination schedule. They can provide personalized advice based on your child's health history and the specific vaccines available in your area. Additionally, they can ensure that your child receives all the necessary vaccinations on time, which is crucial for maintaining immunity against various diseases.

In summary, switching from a four-in-one vaccine to a five-in-one or six-in-one vaccine is generally safe and acceptable, especially in light of vaccine availability and public health recommendations. Always consult with your healthcare provider to ensure that your child receives the best possible care and protection against infectious diseases. Vaccination is a critical component of public health, and staying up-to-date with immunizations is vital for your child's health and the health of the community.

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