Post-Menopausal Care: HPV Testing and Premarin Usage Explained - Obstetrics and Gynecology

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Gynecological issues


Hello, Director Chuang! My mother has had normal results for HPV tests for two consecutive years after menopause, and she has been getting Pap smears regularly every year.
Should she continue to have HPV tests in the future? She has been using Premarin for 4 years; is it safe to use this cream indefinitely? Thank you!

Chico, 30~39 year old female. Ask Date: 2007/08/19

Dr. Zhuang Zhijian reply Obstetrics and Gynecology


Hello, ma'am: Thank you for your inquiry.
I would like to respond to your question and provide the following recommendations: It is important to continue having annual Pap smears as long as the results remain normal.
As for the human papillomavirus (HPV), annual testing may not be necessary.
The use of Premarin should not be indefinite; it is essential to pay attention to the user's symptoms and discomfort, and to closely collaborate with the prescribing physician.
If any abnormalities arise, further in-depth examinations should be conducted promptly, including the possibility of discontinuing the medication.

Reply Date: 2007/08/19

More Info


Post-menopausal care is an important aspect of women's health, particularly when it comes to HPV testing and hormone replacement therapy (HRT) such as Premarin. Your mother's situation raises several pertinent questions regarding the necessity of ongoing HPV testing and the long-term use of Premarin.

Firstly, regarding HPV testing after menopause: The general recommendation is that women should continue to have regular cervical cancer screenings (Pap tests) and HPV testing until they are 65 years old, provided they have had adequate prior screening results. Since your mother has had normal HPV results for the past two years and continues to have annual Pap tests, it may be reasonable to discuss with her healthcare provider whether she should continue HPV testing. The decision often depends on her overall health, history of cervical abnormalities, and the guidelines followed by her healthcare provider. If she has a history of normal results and no other risk factors, her doctor may recommend extending the interval between HPV testing or even discontinuing it after a certain age.

Now, concerning the use of Premarin, which is a form of estrogen used in hormone replacement therapy, it is typically prescribed to alleviate menopausal symptoms such as hot flashes, vaginal dryness, and to prevent osteoporosis. The duration of Premarin use can vary based on individual health needs and risks. While some women may use it for several years, there are considerations regarding the long-term use of estrogen, particularly concerning the risk of breast cancer, cardiovascular disease, and thromboembolic events. Therefore, it is crucial for your mother to have regular follow-ups with her healthcare provider to assess the benefits and risks of continuing Premarin. The healthcare provider may recommend periodic evaluations to determine if the benefits of continued use outweigh any potential risks.

In summary, your mother should continue to have discussions with her healthcare provider about the necessity of ongoing HPV testing based on her individual health history and the latest guidelines. Regarding Premarin, while it can be used for an extended period, it is essential to regularly evaluate its necessity and safety with her doctor. Regular check-ups will help ensure that her menopausal management remains appropriate and beneficial for her overall health.

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