CA 72-4 Levels and Cancer Risk: What You Need to Know

CA 72-4 is a tumor marker primarily associated with gastric cancer, but it can also be elevated in

Hello, my CA72-4 gastric cancer tumor marker is 12.7, which is significantly above the standard.
Could you please tell me what the probability of having cancer is? I have no symptoms of cancer, and my lifestyle is normal, with no alcohol consumption, smoking, or betel nut chewing.
Thank you.

Qiu Xiaojie, 40~49 year old female. Ask Date: 2008/03/11

Dr. Lin Minghui reply Gastroenterology and Hepatology

Hello, Ms.
Chiu.

1.
CA72-4 primarily detects the tumor-associated glycoprotein TAG-72 in the blood, which is secreted by adenocarcinoma cells.
Clinically, it is mainly used for gastrointestinal and ovarian tumors, particularly mucinous ovarian cancer.
Previous studies have reported that if CA72-4 levels exceed the normal value of 20 u/ml, there is a 61% likelihood of gastric cancer and a 35% chance of other cancers.
Additionally, 7% of individuals may have normal or benign conditions, and some healthy individuals may present with elevated CA72-4 levels, while certain cancer patients may have CA72-4 levels within the normal range.
2.
Cancer patients do not always exhibit symptoms.
3.
According to literature reports, the sensitivity of CA72-4 for detecting gastric cancer is 45%, with a specificity of 100%, a positive predictive value of 100%, and a negative predictive value of 7%.
Some studies indicate that CA72-4 is an effective tumor marker for gastric cancer, useful for assessing disease status and postoperative monitoring, and it can also be utilized for follow-up after treatment for colorectal cancer to check for recurrence.
Wishing you good health,
Dr.
Lin Ming-Hui, Taoyuan Hospital, Department of Health

Reply Date: 2008/03/11

More Info

CA 72-4 is a tumor marker that is primarily associated with gastric cancer, but it is important to understand that it is not specific to cancer and can be elevated in various non-cancerous conditions as well. Your reported level of 12.7 is indeed above the normal reference range, which is typically considered to be less than 6.89. However, interpreting this value requires a nuanced understanding of what CA 72-4 levels mean in the context of overall health and potential cancer risk.

Firstly, it is crucial to recognize that tumor markers like CA 72-4 are not definitive diagnostic tools for cancer. They can provide useful information, but they are best used in conjunction with other diagnostic methods. Elevated CA 72-4 levels can be seen in conditions such as gastritis, peptic ulcers, and even infections like Helicobacter pylori, which is known to cause stomach inflammation. Therefore, an elevated CA 72-4 level does not automatically indicate the presence of cancer, especially in the absence of symptoms.

In your case, since you report having no symptoms of cancer and maintain a healthy lifestyle, it is essential to consider other factors. The absence of symptoms such as unexplained weight loss, persistent abdominal pain, changes in bowel habits, or gastrointestinal bleeding is a positive sign. These symptoms often accompany more serious conditions, including cancer, and their absence may suggest that your elevated CA 72-4 level could be due to a benign condition.

Given your elevated CA 72-4 level, it is advisable to follow up with further diagnostic testing. A gastroscopy (endoscopy) could be a valuable next step, as it allows for direct visualization of the stomach lining and the opportunity to take biopsies if necessary. This procedure can help rule out any significant pathology, including cancer, and provide peace of mind.

Additionally, it is important to discuss your concerns with a healthcare provider who can evaluate your individual risk factors, including family history, lifestyle, and any other relevant medical history. They may recommend periodic monitoring of your CA 72-4 levels alongside other relevant tests to track any changes over time.

In summary, while your CA 72-4 level is elevated, it does not definitively indicate cancer, especially in the absence of symptoms. It is essential to pursue further evaluation through appropriate diagnostic tests and maintain open communication with your healthcare provider. Regular monitoring and a proactive approach to your health can help ensure that any potential issues are addressed promptly. Remember, early detection and intervention are key in managing health concerns effectively.

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