Does Taking Olanzapine Affect Fetal Growth During Pregnancy?

Q: Does Taking Olanzapine Affect Fetal Growth During Pregnancy?

Hello： According to current research data, the effects of using Anli Fu tablets during pregnancy show that it can cause teratogenic effects in animals, but evidence in humans is still insufficient. <br>Among all antipsychotic medications, only Clozapine has a pregnancy risk categ

Does taking Otsuka Anri Fukuzan affect fetal growth?

Hello Doctor, I was diagnosed with schizophrenia four years ago.
I am grateful for the compassionate care I have received from doctors, and I have been on medication for a long time.
My current medication has been significantly reduced, and I am able to work in the workplace like a normal person.
Now, I am facing a dilemma: if I continue taking medication, should I consider the possibility of pregnancy? In other words, will this medication affect the healthy growth of the fetus? Schizophrenia has a certain genetic predisposition (although normal individuals can also have children, I understand that the likelihood is higher for patients).
I am mentally prepared to face the potential arrival of a new life (how to educate and pay attention from a young age).
My mental state is currently good, and I understand my condition (I try to avoid negative thoughts about people and not to care about others' words, being kind to others to alleviate any concerns about hearing things).
I also understand that abruptly reducing medication may impact my condition (relapse, physical harm, and in severe cases, lifelong medication may be required).
I have learned that the issues that arise during a relapse may not be the same as those during the initial episode, and I am afraid I may not be able to judge whether I have relapsed again—I'm not sure if this is correct.
However, I also aspire to have a complete family (my husband, myself, and a child).
I have been contemplating this for a long time and struggling with the decision of whether to have a child (I do not want my future child to face the same issues I have, but they could also be a normal person).
If I consider pregnancy, should I gradually stop taking medication or switch to a different medication (are there similar medications that would not affect the fetus) to prevent any impact on the fetus? I sincerely thank you.

Xiao Mi, 20~29 year old female. Ask Date: 2008/03/18

Dr. Lin Yuzhong reply Psychiatry

Hello: According to current research data, the effects of using Anli Fu tablets during pregnancy show that it can cause teratogenic effects in animals, but evidence in humans is still insufficient.
Among all antipsychotic medications, only Clozapine has a pregnancy risk category of B, indicating that it has not shown teratogenic effects in animals, although human data is not complete.
Therefore, the safest approach for the baby would be to discontinue the medication.
However, this may lead to instability in the mother's psychiatric symptoms, making it a challenging issue.
Some individuals choose to stop the medication during the first three months of pregnancy, as this period is when fetal development is most susceptible to influence.
In summary, whether to conceive, discontinue, or change medication is a complex issue.
It is best to discuss this with your physician, as they are most familiar with your condition and can typically provide the best advice.
Reference: Matthew, A., Sajatovic, M.
(2002).
Psychotropic Drug Information Handbook.
(3rd ed.).
Lexi.Comp: United States.

Reply Date: 2008/03/18

More Info

When considering the use of Olanzapine during pregnancy, it's essential to weigh the benefits against the potential risks to both the mother and the developing fetus. Olanzapine is an atypical antipsychotic commonly prescribed for conditions such as schizophrenia and bipolar disorder. It is classified as a Category C medication by the FDA, which means that while animal studies have shown adverse effects on the fetus, there are no well-controlled studies in humans. This classification indicates that the drug should only be used during pregnancy if the potential benefits justify the potential risks to the fetus.

Research has indicated that the use of Olanzapine during pregnancy may be associated with certain risks, including potential impacts on fetal growth and development. Some studies suggest that exposure to antipsychotic medications, including Olanzapine, during pregnancy may increase the risk of complications such as low birth weight, preterm birth, and neonatal withdrawal symptoms. Additionally, there is some evidence to suggest that the use of antipsychotics during pregnancy may be linked to an increased risk of congenital malformations, although the data is not conclusive.

Given the complexities of managing mental health conditions during pregnancy, it is crucial to have an open and honest discussion with your healthcare provider. They can help assess your individual situation, considering factors such as the severity of your mental health condition, your current treatment regimen, and the potential risks associated with continuing or discontinuing Olanzapine.
If you are considering pregnancy, it may be advisable to explore alternative treatment options that are classified as safer during pregnancy, such as certain antidepressants or mood stabilizers that fall into Category A or B. However, any changes to your medication should be made under the guidance of a healthcare professional, as abrupt discontinuation of Olanzapine can lead to a relapse of your mental health condition, which can also pose risks to both you and your baby.

Moreover, it is important to consider the genetic aspects of mental health conditions. While there is a hereditary component to schizophrenia and other psychiatric disorders, many individuals with a family history of these conditions go on to have healthy children without any mental health issues. The decision to have children should take into account not only the potential risks associated with medication but also your overall mental health stability and support system.

In summary, if you are taking Olanzapine and are considering pregnancy, it is essential to consult with your healthcare provider. They can help you evaluate the risks and benefits of continuing your medication, explore alternative treatments, and develop a comprehensive plan that prioritizes both your mental health and the health of your future child. Your mental well-being is crucial not only for you but also for your family, and with the right support and management, it is possible to navigate this challenging situation.

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