Vaccination Fever in Infants: What Parents Need to Know - Pediatrics

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Fever after vaccination


Can my baby, who is one and a half months old, receive the hexavalent vaccine? He developed a fever after the vaccination, and I wonder if it was too early for him to get vaccinated.
What should I do if he has a fever after the vaccine? Is a temperature of 38.7°C too high? After taking antipyretics, his temperature is still 37.9°C six hours later; what should I do?

You worried Huang Mama, 30~39 year old female. Ask Date: 2009/05/14

Dr. Xiao Kaiwen reply Pediatrics


It is not too early for a one-and-a-half-month-old infant to receive the first dose of the hexavalent vaccine.
Although the hexavalent vaccine has a significantly lower chance of causing fever compared to older vaccines, approximately one in fifty to sixty recipients may still experience a fever.
Fever is the most common side effect of vaccines, but it typically does not last longer than 24 to 48 hours and is not harmful to the body.
If the infant's activity level and appetite are normal, there is no need for excessive concern.
It is advisable to have some antipyretics on hand and to monitor the situation.
However, if the fever persists beyond 24 to 48 hours or if the infant shows poor activity levels even without a fever, it may not be related to the vaccine, and it is recommended to consult a pediatrician for further evaluation.

Reply Date: 2009/05/14

More Info


Vaccination is a crucial aspect of preventive healthcare for infants and children, and it is common for parents to have concerns about potential side effects, including fever, following vaccination. In your case, your one-and-a-half-month-old baby is eligible for the hexavalent vaccine (六合一), which protects against six diseases: diphtheria, tetanus, pertussis, polio, Haemophilus influenzae type b (Hib), and hepatitis B.
It is important to understand that fever can be a normal response to vaccination. The immune system is activated when a vaccine is administered, and this can lead to an increase in body temperature as the body builds immunity. Typically, a mild fever (up to 38.5°C or 101.3°F) is expected and is not usually a cause for concern. However, if the fever exceeds 38.5°C, as in your case where it reached 38.7°C, it is understandable to be worried.

Here are some steps you can take if your baby develops a fever after vaccination:
1. Monitor the Fever: Keep an eye on your baby's temperature. If it remains below 39°C (102.2°F) and your baby is otherwise acting normally (eating, drinking, and playing), it is generally safe to manage the fever at home.

2. Use Fever-Reducing Medication: If your baby seems uncomfortable or the fever is high, you can administer age-appropriate doses of acetaminophen (Tylenol) or ibuprofen (Advil, Motrin) as recommended by your pediatrician. However, do not give aspirin to children, as it is associated with Reye's syndrome, a serious condition.

3. Hydration: Ensure your baby stays hydrated. Offer breast milk or formula frequently. Hydration is crucial, especially if your baby has a fever.

4. Comfort Measures: Dress your baby in lightweight clothing and keep the room at a comfortable temperature. You can also use a lukewarm sponge bath to help lower the fever.

5. When to Seek Medical Attention: If your baby's fever persists for more than 24 hours, reaches 39.4°C (103°F) or higher, or if your baby exhibits any concerning symptoms (such as lethargy, difficulty breathing, persistent crying, or rash), you should contact your pediatrician or seek medical attention immediately.

6. Follow-Up: After vaccination, it is also important to have a follow-up appointment with your pediatrician to discuss any concerns and ensure your baby is developing normally.

In summary, while a fever after vaccination can be alarming for parents, it is often a normal response as the body builds immunity. Monitoring your baby's condition and knowing when to seek help can provide peace of mind. Always consult with your healthcare provider for personalized advice and recommendations based on your baby's health history and current condition.

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