Is the New 5-in-1 Vaccine Safer for My 4-Month-Old? - Pediatrics

Share to:

New pentavalent vaccine


My son is currently four months old.
He had a fever of 38.9°C after receiving the hexavalent vaccine for both the first and second doses.
I went to another clinic, and the doctor suggested switching to the new pentavalent vaccine along with an additional dose of hepatitis B vaccine.
He mentioned that the new pentavalent vaccine is less likely to cause fever.
Is this a good option? Also, since different clinics use different brands of vaccines, will this have any impact? Thank you!

Youying de Huang Mama, 30~39 year old female. Ask Date: 2009/08/05

Dr. Xiao Kaiwen reply Pediatrics


It is generally better to use vaccines from the same manufacturer (to ensure the antigens are the same).
If a child experiences a fever after receiving the hexavalent vaccine, it is important to note that the fever caused by the vaccine does not harm the infant and typically resolves within 24 hours.
However, if the discomfort of the baby and the caregiver is a concern, it may be considered to switch to the "same manufacturer (GlaxoSmithKline)" pentavalent vaccine, along with an additional dose of hepatitis B vaccine.
This approach will not affect the efficacy of the vaccines, but the baby will need to receive an extra injection, which may cause some additional discomfort.

Reply Date: 2009/08/05

More Info


When considering the safety and efficacy of vaccines for your 4-month-old son, it’s important to understand the differences between the vaccines available and the potential side effects associated with them. The new 5-in-1 vaccine that your doctor recommended is designed to combine multiple vaccinations into a single shot, which can be beneficial in reducing the number of injections your child needs to receive.
The 5-in-1 vaccine typically protects against five diseases: diphtheria, tetanus, pertussis (whooping cough), polio, and Haemophilus influenzae type b (Hib). The traditional 6-in-1 vaccine adds protection against hepatitis B. If your child has previously experienced a fever of 38.9°C after receiving the 6-in-1 vaccine, it is understandable that you would be concerned about potential side effects from future vaccinations.

The new 5-in-1 vaccine may indeed have a different formulation that could lead to fewer side effects, including fever. However, it is important to note that fever is a common and generally harmless reaction to vaccinations, indicating that the immune system is responding to the vaccine. While it can be uncomfortable for both the child and the caregivers, it typically resolves within 24 hours.
Switching to the new 5-in-1 vaccine, along with an additional dose of the hepatitis B vaccine, is generally considered safe and should not significantly impact the effectiveness of the immunization schedule. The key point is to ensure that the vaccines are from the same manufacturer when possible, as this can help maintain consistency in the immune response. Different brands may have variations in their formulations, which could potentially lead to different side effects or efficacy profiles.
Regarding your concern about the use of different brands at various clinics, it is advisable to keep a record of the vaccines your child has received, including the brand names. If you switch brands, it’s best to consult with your healthcare provider to ensure that the vaccines are compatible and that your child is receiving the appropriate immunizations according to the recommended schedule.

In summary, switching to the new 5-in-1 vaccine, along with an additional hepatitis B dose, can be a good option for your son, especially if it may lead to fewer side effects. Always consult with your pediatrician or healthcare provider about any concerns you have regarding vaccinations, as they can provide personalized advice based on your child's health history and current guidelines. Keeping an open line of communication with your healthcare provider will help ensure that your child receives the best possible care.

Similar Q&A

Can I Administer 5-in-1 Vaccine to My 1.5-Year-Old Child?

The child is currently 1 year and 6 months old. They received the 5-in-1 vaccine at 2 months and 4 months, and the 4-in-1 vaccine at 6 months. The 4-in-1 vaccine is currently out of stock. Can the child receive the 5-in-1 vaccine instead? Is this dosage sufficient? Thank you.


Dr. Xie Degui reply Pediatrics
The pentavalent vaccine can be administered, and the dosage is the same.

[Read More] Can I Administer 5-in-1 Vaccine to My 1.5-Year-Old Child?


Concerns After 5-in-1 Vaccine: What Parents Should Know

My baby is now two months old, and when I took him to get the DTaP-Hib-IPV-HepB (5-in-1) vaccine, the nurse administered it. Afterward, while preparing to give the oral Sabin vaccine, I reminded her that it was the 5-in-1 vaccine that was given. She responded that the 5-in-1 vacc...


Dr. Liang Hongjian reply Pediatrics
Hello: Every type of vaccine carries varying degrees of risk. The likelihood of developing complications from Japanese encephalitis after receiving the vaccine, according to the literature, is very low. Currently, your situation involves an excessive amount of vaccine, which may ...

[Read More] Concerns After 5-in-1 Vaccine: What Parents Should Know


Can My Baby Get the Five-in-One Vaccine at Four Months?

Hello, doctor: My baby received the first dose of the DTaP (diphtheria, tetanus, and pertussis) vaccine when he/she was two months old. Now that he/she is four months old, I would like to know if it is possible to administer the pentavalent vaccine (DTaP-Hib-IPV-HepB).


Dr. Zhang Jinglong reply Pediatrics
You can go to a nearby pediatric medical facility for the injection.

[Read More] Can My Baby Get the Five-in-One Vaccine at Four Months?


Choosing the Right Vaccine for Your Toddler: Six-in-One vs. Four or Five-in-One

Hello Dr. Hsiao: My baby is now 1.5 years old and is due for the hexavalent vaccine! However, when I called the previous hospital (Hospital A) where we received vaccinations, they informed me that they are currently out of stock and can only offer the pentavalent or quadrivalent ...


Dr. Xiao Kaiwen reply Pediatrics
Currently, the six-in-one vaccine available on the market is exclusively from the BabyCare brand (GlaxoSmithKline). In principle, if the six-in-one vaccine is out of stock, the Department of Health recommends administering the five-in-one or four-in-one vaccine for the fourth dos...

[Read More] Choosing the Right Vaccine for Your Toddler: Six-in-One vs. Four or Five-in-One


Related FAQ

Vaccine

(Pediatrics)

Covid-19 Vaccine

(Pediatrics)

Infant Formula

(Pediatrics)

Enterovirus

(Pediatrics)

Lymph

(Pediatrics)

Purpura

(Pediatrics)

Gastrointestinal

(Pediatrics)

Cough

(Pediatrics)

Pediatric Asthma

(Pediatrics)

Fever

(Pediatrics)