Lexapro and Anesthesia: What Anxiety Patients Need to Know - Psychiatry

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Dear Doctor, I am a patient with anxiety disorder and I take 2 tablets of Lexapro (escitalopram) every morning and evening.
I am scheduled for surgery with general anesthesia soon.
Will this medication have any adverse effects on general anesthesia?

Steve, 30~39 year old female. Ask Date: 2009/08/17

Dr. Zhan Hongyu reply Psychiatry


Hello: As far as current medical information indicates, there are no significant adverse reaction reports regarding Lexapro (escitalopram) and anesthetic agents.
However, before undergoing surgery with general anesthesia, please inform your surgeon that you are taking Lexapro and discuss whether any medication adjustments are necessary prior to the procedure.
Wishing you good health.
Sincerely, Dr.
Jan Hong-Yu.

Reply Date: 2009/08/17

More Info


When it comes to the use of Lexapro (escitalopram) in patients undergoing general anesthesia, there are several important considerations to keep in mind. Lexapro is a selective serotonin reuptake inhibitor (SSRI) commonly prescribed for anxiety and depression. While it is generally considered safe to continue taking SSRIs like Lexapro during the perioperative period, there are specific factors that both patients and healthcare providers should be aware of.

First and foremost, it is crucial to communicate openly with your anesthesiologist and surgical team about all medications you are currently taking, including Lexapro. This allows them to make informed decisions regarding your anesthesia plan. SSRIs can interact with certain anesthetic agents, but the risk of significant adverse effects is relatively low. However, some studies suggest that patients on SSRIs may experience a higher incidence of bleeding due to the potential effects of these medications on platelet function. This is particularly relevant if you are undergoing surgery that involves significant blood loss or requires extensive tissue manipulation.

Additionally, anxiety and depression can complicate the surgical experience. Patients with anxiety disorders may have heightened responses to stress, which can affect their overall recovery. Therefore, it is essential to manage your anxiety effectively before and after surgery. Continuing your Lexapro regimen may help stabilize your mood and anxiety levels, which can contribute to a smoother surgical experience and recovery.

In terms of whether you should stop taking Lexapro before surgery, most healthcare providers recommend continuing the medication unless specifically instructed otherwise. Abruptly discontinuing SSRIs can lead to withdrawal symptoms and a potential exacerbation of anxiety or depressive symptoms, which could be counterproductive, especially in the context of surgery. Your anesthesiologist may provide specific guidelines based on your individual health status and the type of surgery you are undergoing.

Moreover, it is essential to consider the timing of your medication. If your surgery is scheduled for the morning, you may be advised to take your Lexapro as usual unless instructed to fast. If your surgery is later in the day, you might need to adjust your medication schedule accordingly, but this should always be done under the guidance of your healthcare provider.

Lastly, post-operative care is also crucial. After surgery, you may experience increased anxiety due to pain, discomfort, or the effects of anesthesia. It is important to have a plan in place for managing these symptoms, which may include continuing your Lexapro and possibly incorporating additional support, such as therapy or counseling, to help you cope with any post-operative anxiety.

In summary, Lexapro is generally safe to continue during the perioperative period, but it is vital to communicate with your healthcare team about your medication regimen. They will consider your specific situation, including the type of surgery and your overall health, to provide the best recommendations. Maintaining your mental health stability through the surgical process is essential for a successful outcome, so do not hesitate to reach out for support and guidance from your healthcare providers.

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