Fatty Liver: AST, ALT, and Dietary Recommendations - Gastroenterology and Hepatology

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Fatty liver disease


Hello Doctor, I would like to ask if the AST and ALT liver function tests are what is commonly referred to as GOT and GPT? Last week, my blood test results were 63 and 108.
The doctor mentioned that I have fatty liver (without hepatitis B or C and no history of alcohol consumption).
Three months ago, my results were 49 and 81.
The doctor prescribed liver medication, and I have diabetes (but my blood sugar is well-controlled with medication).
However, my triglycerides are elevated (261), and I am taking lipid-lowering medication.
The doctor mentioned that there is a very effective lipid-lowering medication that could raise liver enzyme levels, so he is hesitant to prescribe it.
Isn’t it possible for lipid-lowering medications to also help with fatty liver? I don’t quite understand.
I live in the mountains, and the doctor at the medical station suggested that I go to the hospital to see a specialist for an ultrasound to determine the extent of my fatty liver before starting medication.
Do I need to make an appointment, or can it be done immediately? Additionally, I’ve heard that drinking clam essence can lower liver enzyme levels.
Is this suitable for fatty liver patients? What are some liver-friendly foods that are generally recommended for those with fatty liver? I have many questions, and I appreciate your help.
Thank you for your answers.

Ding Ding, 30~39 year old female. Ask Date: 2009/10/29

Dr. Chen Shidian reply Gastroenterology and Hepatology


Hello, Sir:
1.
AST = GOT; ALT = GPT.

2.
The main treatment for fatty liver is weight loss and exercise; certain diabetes medications can also be helpful, primarily due to metabolic syndrome.
Liver-protective medications and clam extract have limited benefits.

3.
Ultrasound has limited utility (but can check for gallstones, etc.).

4.
Lipid-lowering medications (statins) may cause a slight increase in GPT; however, they can be used cautiously if necessary (in cases of high cholesterol).

Changhua Hospital cares about your health.

Chen Shidian

Reply Date: 2009/10/29

More Info


Understanding fatty liver disease, particularly in the context of elevated liver enzymes such as AST (aspartate aminotransferase) and ALT (alanine aminotransferase), is crucial for managing your health. To clarify, AST and ALT are indeed the same as GOT (glutamate oxaloacetate transaminase) and GPT (glutamate pyruvate transaminase), respectively. Your recent blood test results of 63 for AST and 108 for ALT indicate elevated liver enzymes, which can be a sign of liver inflammation or damage, often associated with fatty liver disease.

Fatty liver disease, particularly non-alcoholic fatty liver disease (NAFLD), is commonly linked to metabolic conditions such as obesity, diabetes, and dyslipidemia (high triglycerides and cholesterol levels). In your case, the presence of diabetes and elevated triglycerides (261 mg/dL) suggests a metabolic syndrome that can exacerbate liver issues. The liver plays a vital role in metabolizing fats and sugars, and when it becomes overloaded with fat, it can lead to inflammation and potentially progress to more severe liver conditions.

Regarding treatment, the primary approach for fatty liver disease involves lifestyle modifications, including weight loss, dietary changes, and increased physical activity. While certain medications can help manage triglyceride levels, some, like statins, may cause a slight increase in liver enzymes. Therefore, it's essential to balance the benefits of lowering cholesterol with the potential risks to liver health. Your doctor’s caution in prescribing such medications is warranted, especially given your elevated liver enzymes.

As for the ultrasound, it is a non-invasive procedure that can help determine the extent of fatty liver and rule out other liver conditions. It is advisable to schedule an appointment with a specialist, as they can provide a more comprehensive evaluation and tailored treatment plan. Depending on the facility, you may need to make an appointment in advance, so it’s best to check with the hospital.

Regarding dietary recommendations, while there is no specific "liver detox" food, a balanced diet rich in whole foods can support liver health. Foods that are generally beneficial for individuals with fatty liver include:
1. Fruits and Vegetables: High in fiber and antioxidants, they help reduce inflammation and improve overall health. Aim for a variety of colors to get a range of nutrients.

2. Whole Grains: Foods like brown rice, quinoa, and whole wheat bread can help maintain stable blood sugar levels and provide essential nutrients.

3. Lean Proteins: Sources such as chicken, turkey, fish, and plant-based proteins (like beans and lentils) are preferable to red and processed meats.

4. Healthy Fats: Incorporate sources of omega-3 fatty acids, such as fatty fish (salmon, mackerel), walnuts, and flaxseeds, while reducing saturated fats found in fried and processed foods.

5. Low Sugar and Refined Carbohydrates: Limiting sugar intake and avoiding refined carbs can help manage both liver health and blood sugar levels.

As for the claim about drinking clam essence to lower liver enzymes, while some natural products are marketed for liver health, scientific evidence supporting their efficacy is often limited. It's essential to consult with your healthcare provider before trying any new supplements or remedies, especially if you have existing health conditions.

In conclusion, managing fatty liver disease requires a multifaceted approach that includes regular monitoring of liver enzymes, lifestyle modifications, and dietary changes. Collaborating with healthcare professionals, including a dietitian, can provide you with personalized strategies to improve your liver health and overall well-being. Regular follow-ups and adherence to medical advice are crucial in preventing the progression of liver disease.

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