the Side Effects of Risperidone in Schizophrenia Treatment - Psychiatry

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Side effects of Risperidone?


Hello Dr.
Chang,
I have seen a doctor who diagnosed me with latent schizophrenia.
I have been taking Risperidone at a dosage of approximately 1 mg per day for the past two years.
Recently, I have been troubled by a situation where it feels like my left eyelid keeps drooping.
I would like to know if this could be a side effect of long-term Risperidone use, and if so, how can I improve this condition? Thank you.

Fisk, 20~29 year old female. Ask Date: 2009/11/07

Dr. Zhang Zhehong reply Psychiatry


Please consult your psychiatrist to confirm the diagnosis and differentiate the following drug-induced Parkinsonism symptoms:
1.
Resting tremor: Involuntary shaking of one or both arms.
Tremors may also occur in the legs, feet, or chin.

2.
Rigidity: Persistent central nervous system muscle stiffness, leading to muscle pain or an inability to straighten the body.

3.
Bradykinesia: Symptoms include reduced facial expressions and curled toes.
Myasthenia Gravis: The primary symptom is fluctuating weakness in certain muscles, which may present as follows:
1.
Ptosis (drooping eyelids), which may vary in severity between the two eyes.

2.
Diplopia (double vision).

3.
Dysarthria (slurred speech) or hoarseness, with increasing weakness as speaking continues.

4.
Difficulty chewing or swallowing food, which may prolong meal times significantly.

5.
Tasks requiring arm elevation, such as combing hair, shaving, or writing on a blackboard, may start off manageable but become impossible after repeated attempts; resting allows for a brief return to function.

6.
Climbing stairs may require frequent breaks due to thigh muscle weakness.

7.
In severe cases of muscle weakness, patients may be unable to swallow saliva, clear phlegm, or breathe properly.

Reply Date: 2009/11/07

More Info


Risperidone, marketed under the brand name Risperdal, is an atypical antipsychotic medication commonly used to treat schizophrenia, bipolar disorder, and irritability associated with autistic disorder. While it can be effective in managing symptoms of these conditions, it is also associated with a range of potential side effects, particularly when used over an extended period.

One of the concerns with long-term use of Risperidone is the risk of extrapyramidal symptoms (EPS), which include movement disorders such as tremors, rigidity, and tardive dyskinesia. The symptom you described—your left eyelid drooping—could potentially be related to these types of side effects, particularly if it manifests as a form of involuntary movement or muscle control issue. Tardive dyskinesia, for instance, can lead to abnormal movements of the face and body, which might include eyelid spasms or drooping.

In addition to EPS, Risperidone can also lead to metabolic side effects, such as weight gain and changes in glucose and lipid metabolism, which can increase the risk of diabetes and cardiovascular issues. Other common side effects include sedation, dizziness, and hormonal changes, such as increased prolactin levels, which can lead to galactorrhea (milk production) or gynecomastia (breast tissue development in men).

If you are experiencing persistent eyelid drooping, it is essential to discuss this with your prescribing physician. They may consider several options, including:
1. Medication Adjustment: Your doctor might evaluate the dosage of Risperidone you are taking. Sometimes, reducing the dose or switching to another antipsychotic with a lower risk of EPS may alleviate the symptoms.

2. Addition of Medications: In some cases, doctors may prescribe medications to counteract the side effects of antipsychotics, such as anticholinergic agents (e.g., benztropine) that can help manage EPS.

3. Monitoring and Evaluation: Regular follow-ups are crucial for anyone on long-term antipsychotic therapy. Your doctor may want to monitor your symptoms closely and adjust your treatment plan as necessary.

4. Lifestyle Modifications: Engaging in regular physical activity, maintaining a balanced diet, and monitoring your weight can help mitigate some of the metabolic side effects associated with Risperidone.

5. Consultation with a Specialist: If the eyelid drooping persists or worsens, your doctor may refer you to a neurologist or a psychiatrist specializing in movement disorders for further evaluation.

It's important to remember that while medications like Risperidone can be very effective in managing psychiatric symptoms, they can also have significant side effects, especially with long-term use. Open communication with your healthcare provider is vital to ensure that you receive the most appropriate care tailored to your needs. If you have concerns about your current treatment or side effects, do not hesitate to bring them up during your next appointment. Your health and well-being should always be the priority in your treatment plan.

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