Impact of Mebendazole on Pregnancy: What You Need to Know - Pharmacology

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I took Mebendazole to treat viral warts and then discovered that I am pregnant?


Hello...
I took Mebendazole for three days on January 22, January 30, and February 6 (one tablet in the morning and one in the evening each day, totaling six tablets) to treat viral warts.
However, I did not take the medication consistently and only consumed about three tablets per week, which is half the recommended dosage.
I unexpectedly discovered that I am pregnant on February 14.
Could this affect the fetus? Thank you for your response.

Jiao Lü De Mama, 30~39 year old female. Ask Date: 2010/02/24

Dr. Hou Fangmin reply Pharmacology


Hello: It is very important to be cautious when using medications during pregnancy, especially in the early stages.
The medication you are using, Mebendazole, is used to treat roundworms, whipworms, and pinworms, but its safety during pregnancy has not been established.
It is classified as Category C, which means that animal studies have shown adverse effects on the embryo (teratogenic or embryotoxic effects), but there have been no studies conducted on pregnant women.
There are also no controlled studies in pregnant women or animal studies available.
This medication should only be used if the potential benefits outweigh the risks.

If you have viral warts, you can consider cryotherapy with nitrogen, which is an external treatment.
However, warts may recur because they are easily transmissible.
Since you are currently 5 weeks pregnant, it is best for you to consult an obstetrician-gynecologist for advice.
I apologize for causing you anxiety, and I sincerely wish you a healthy baby.
Goodbye.

Reply Date: 2010/02/24

More Info


Mebendazole is an anthelmintic medication primarily used to treat parasitic worm infections. However, its use during pregnancy raises significant concerns due to potential risks to the developing fetus. According to the FDA's pregnancy classification system, Mebendazole is categorized as a Category C drug. This classification indicates that animal studies have shown adverse effects on the fetus, but there are no well-controlled studies in pregnant women. Therefore, the use of Mebendazole during pregnancy should be approached with caution.

In your case, you mentioned taking Mebendazole on several occasions before discovering your pregnancy. While you did not adhere strictly to the prescribed dosage, it is essential to understand that any exposure to medications during the early stages of pregnancy can be concerning. The first trimester is a critical period for fetal development, as this is when the major organs and systems are forming. The potential risks associated with Mebendazole include teratogenic effects, which could lead to congenital abnormalities.

Given that you took Mebendazole during the early weeks of your pregnancy, it is advisable to consult with a healthcare professional, preferably an obstetrician or a maternal-fetal medicine specialist. They can provide personalized guidance based on your specific situation and medical history. It is essential to discuss your concerns openly, as they may recommend additional monitoring or tests to ensure the health of your pregnancy.

In general, if a pregnant woman has taken a medication that is classified as potentially harmful, healthcare providers often recommend close monitoring through ultrasounds and other assessments to check for any developmental issues. However, it is crucial to remember that not all medications will lead to adverse outcomes, and many pregnancies result in healthy babies despite early medication exposure.

In addition to consulting with your healthcare provider, it may be beneficial to focus on maintaining a healthy lifestyle during your pregnancy. This includes a balanced diet, regular prenatal care, and avoiding any unnecessary medications or substances that could pose risks to your developing baby.

In summary, while Mebendazole is associated with potential risks during pregnancy, the actual impact on your fetus will depend on various factors, including the timing and dosage of the medication. Seeking professional medical advice is the best course of action to address your concerns and ensure the health and safety of both you and your baby.

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