Are Predonine and the Hexagonal Pill Equivalent in Effectiveness? - Pharmacology

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Steroid Prednisone Tablets


The hospital outpatient prescribed Predonine 5mg, which has a round shape with the imprint of 5 and 341.
However, when I went to the community pharmacy with the prescription, I received a medication that is also round but has a hexagonal protrusion and the imprint of 157.
Are these two medications the same? Will there be any difference in their effects?

tony, 20~29 year old female. Ask Date: 2012/03/26

Dr. Liao Lingmei reply Pharmacology


Dear: Predonine is produced by the pharmaceutical company Shionogi and contains the active ingredient Prednisolone 5mg.
The medication you received from the community pharmacy may be "Dexamethasone Tablets 5mg" produced by Veterans Pharmaceutical Company, which also contains Prednisolone 5mg.
Both medications have the same active ingredient and dosage, and they should have comparable effects, but they are manufactured by different companies.
Please confirm the accuracy with your community pharmacist.
Wishing you all the best! Stay healthy and happy!

Reply Date: 2012/03/26

More Info


When it comes to comparing medications, particularly those that may appear similar but have different formulations or active ingredients, it's essential to understand their specific uses, effectiveness, and potential side effects. In your case, you are inquiring about Predonine (Prednisone) and another medication that you received, which is a hexagonal pill marked with "157."
Predonine (Prednisone) is a synthetic corticosteroid that is commonly used to reduce inflammation and suppress the immune system. It is effective in treating a variety of conditions, including allergies, autoimmune diseases, and certain types of cancer. The effectiveness of Prednisone is well-established, and it is typically prescribed in a specific dosage tailored to the patient's needs.

On the other hand, the hexagonal pill you received, marked with "157," is identified as Dexamethasone, another corticosteroid. While both Prednisone and Dexamethasone belong to the same class of drugs and have similar anti-inflammatory effects, they are not identical in terms of potency, duration of action, and specific indications.

Key Differences:
1. Potency: Dexamethasone is generally considered to be more potent than Prednisone. This means that a lower dose of Dexamethasone may be required to achieve the same anti-inflammatory effect as a higher dose of Prednisone.

2. Duration of Action: Dexamethasone has a longer half-life compared to Prednisone, which means it stays in the body longer and may provide a more prolonged effect. This can be beneficial in certain clinical situations but may also lead to different side effects.

3. Indications: While both medications can be used for similar conditions, there are specific scenarios where one may be preferred over the other. For example, Dexamethasone is often used in acute situations, such as severe allergic reactions or as part of cancer treatment protocols, while Prednisone may be used for chronic conditions.

4. Side Effects: Both medications share similar side effects, such as increased appetite, weight gain, mood changes, and potential suppression of the adrenal gland function with long-term use. However, the risk and severity of side effects may vary based on the specific drug and dosage.

Conclusion:
In summary, while Predonine (Prednisone) and the hexagonal pill (Dexamethasone) are both corticosteroids and can be used to treat similar conditions, they are not equivalent in effectiveness. The choice between these medications should be based on the specific clinical scenario, the patient's medical history, and the prescribing physician's judgment. If you have concerns about the medication you received or its effectiveness compared to what was originally prescribed, it is crucial to discuss this with your healthcare provider. They can provide personalized advice and ensure that you are receiving the most appropriate treatment for your condition. Always consult your doctor or pharmacist before making any changes to your medication regimen.

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