Favism
Can children with G6PD deficiency use "Azelaic Acid" prescribed by a dermatologist?
Jia Jia, 0~9 year old female. Ask Date: 2012/07/03
Dr. Wu Zhengfen reply Pharmacology
To Jia-Jia: 1.
When seeking medical treatment or medication, you must actively inform your physician and pharmacist that you have G6PD deficiency to avoid using contraindicated medications.
2.
Never take medications without a prescription; all medications should be prescribed by a physician to ensure your safety.
3.
Avoid using mothballs in your home environment, closet, and bathroom.
4.
Do not use solutions containing gentian violet, such as purple dye, when injured or during oral candidiasis.
5.
Avoid eating fava beans and their products.
6.
If you experience yellowing of the skin, pallor, or dark-colored urine, seek medical attention immediately; do not delay.
Patients with G6PD deficiency should avoid the following medications: 1.
Antimalarial drugs, such as primaquine, pamaquine, pentaquine, and plasmoquine.
2.
Sulfonamide antibiotics, such as sulfanilamide, sulfapyridine, sulfisoxazole, sulfacetamide, salicylazosulfapyridine, and sulfamethoxypyridazine.
3.
Antipyretic and analgesic medications, such as aspirin, acetanilide, phenacetin, antipyrine, aminopyrine, and p-aminosalicylic acid.
4.
Certain antibiotics or disinfectants, such as nitrofurantoin, furazolidone, and furaltadone.
5.
Other chemicals, such as naphthalene, gentian violet, methylene blue, phenylhydrazine, acetylphenylhydrazine, probenecid (a uricosuric agent), and sulfoxone.
If you are unsure whether the medication prescribed by the dermatologist, such as rhododendron acid, contains other components, it is advisable to inform the original dermatology clinic about your G6PD deficiency before deciding whether it can be used.
Thank you.
Reply Date: 2012/07/03
More Info
Favism, also known as G6PD deficiency, is a genetic condition that affects the red blood cells and can lead to hemolytic anemia when exposed to certain triggers, including specific foods, medications, and chemicals. When it comes to skincare products, particularly those containing active ingredients like rhododendron acid (also known as azelaic acid), it is crucial to consider the safety and potential risks for children with this condition.
Rhododendron acid is often used in dermatology for its anti-inflammatory and keratolytic properties, making it effective in treating acne and other skin conditions. However, the safety of using such products in children with favism is not well-documented. The primary concern is that some ingredients in topical formulations can potentially trigger a reaction in individuals with G6PD deficiency, although rhododendron acid itself is not commonly listed among the known triggers.
When considering the use of any topical treatment for a child with favism, it is essential to review the entire ingredient list of the product. Ingredients such as menthol, camphor, and certain preservatives can be problematic for individuals with G6PD deficiency. Therefore, it is advisable to avoid products that contain these substances.
In addition to the ingredient concerns, the skin of children is generally more sensitive than that of adults. This means that even if a product is deemed safe for use in the general population, it may still cause irritation or an allergic reaction in a child. For this reason, it is always best to conduct a patch test before applying any new product extensively. This involves applying a small amount of the product to a discreet area of the skin and observing for any adverse reactions over 24 to 48 hours.
Moreover, consulting with a pediatric dermatologist or a healthcare provider who is knowledgeable about favism is crucial. They can provide personalized recommendations based on the child's specific health history and skin condition. If rhododendron acid is deemed appropriate, the healthcare provider may suggest a lower concentration or a different formulation that minimizes potential risks.
In summary, while rhododendron acid may not be a direct contraindication for children with favism, caution is warranted. Always check the full ingredient list for any potential triggers, perform a patch test, and consult with a healthcare professional before starting any new skincare regimen. This approach ensures that the treatment is both safe and effective for the child's unique needs.
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