Alternative Treatments for Acne Beyond Diane-35: What Are Your Options? - Dermatology

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In addition to Diane-35 for treating acne, are there other methods available?


Hello Doctor: After examination, I found out that I have an excess of male hormones.
I have never had acne before, but now at the age of 30, I am experiencing persistent breakouts, which worsen due to increased body heat before my menstrual period.
The doctor recommended that I take Diane-35 for treatment.
I have been on it for three months; can I continue? Are there other methods to help with my acne and acne scars? I kindly request your prompt response.
Thank you!

sam, 30~39 year old female. Ask Date: 2002/02/21

Dr. Chen Yiying reply Dermatology


Diane is a contraceptive pill containing anti-androgens used for the treatment of delayed acne.
In fact, it typically takes more than three cycles of use for the effects to become noticeable.
Therefore, as long as you are not experiencing any discomfort and do not have immediate plans for pregnancy, it is important not to rush into stopping the medication if you want to see treatment results.
It is recommended that you continue using it.
Of course, there are many other treatments for acne, but these should be chosen in consultation with a dermatologist to find the most suitable option for you.
Based on your described situation, Diane seems to be a suitable treatment method for you, and it can be complemented with some topical medications.
Most importantly, do not rush the treatment of acne; please work closely with your dermatologist.
Wishing you a speedy return to beautiful skin.

Reply Date: 2002/02/21

More Info


When considering alternative treatments for acne beyond Diane-35, it's essential to understand the underlying causes of acne, particularly in the context of hormonal imbalances. Diane-35, which contains cyproterone acetate and ethinylestradiol, is often prescribed for acne due to its anti-androgenic properties, which can help reduce sebum production and improve skin condition. However, if you've been on Diane-35 for three months and are still experiencing significant acne, it may be time to explore other options.

1. Topical Treatments: Over-the-counter topical treatments containing benzoyl peroxide, salicylic acid, or retinoids can be effective for mild to moderate acne. Benzoyl peroxide works by killing acne-causing bacteria, while salicylic acid helps to unclog pores. Retinoids, such as adapalene, promote cell turnover and can prevent clogged pores.

2. Antibiotics: For more severe cases, dermatologists may prescribe topical or oral antibiotics to reduce inflammation and bacterial growth. Common options include clindamycin and tetracycline. However, it's crucial to use antibiotics judiciously to avoid antibiotic resistance.

3. Hormonal Treatments: If hormonal imbalance is a significant factor in your acne, other hormonal treatments may be considered. Besides Diane-35, other combined oral contraceptives (COCs) that contain different progestins may also help manage acne. Spironolactone, a medication that blocks androgen receptors, can be particularly effective for women with hormonal acne.

4. Isotretinoin: For severe, persistent acne that does not respond to other treatments, isotretinoin (commonly known by the brand name Accutane) may be an option. This powerful medication reduces sebum production and has long-lasting effects. However, it comes with potential side effects and requires careful monitoring by a healthcare provider.

5. Chemical Peels and Laser Therapy: Dermatological procedures such as chemical peels or laser therapy can help improve skin texture and reduce acne scarring. These treatments work by exfoliating the skin and promoting new skin growth.

6. Lifestyle Modifications: In addition to medical treatments, lifestyle changes can also play a significant role in managing acne. Maintaining a balanced diet, staying hydrated, managing stress, and practicing good skincare hygiene can all contribute to healthier skin. Avoiding heavy makeup and using non-comedogenic products can also help prevent clogged pores.

7. Dietary Considerations: Some studies suggest that certain dietary factors, such as high glycemic index foods and dairy products, may exacerbate acne. A diet rich in whole foods, fruits, vegetables, and omega-3 fatty acids may help improve skin health.

8. Consultation with a Dermatologist: Given your specific situation, it would be beneficial to consult with a dermatologist who can provide personalized recommendations based on your skin type, hormonal levels, and overall health. They can help determine whether to continue with Diane-35 or explore alternative treatments.

In conclusion, while Diane-35 can be effective for treating hormonal acne, it may not be the only or best option for everyone. Exploring a combination of topical treatments, hormonal therapies, and lifestyle changes, along with professional guidance, can lead to better management of acne and improvement in skin appearance. Always consult with your healthcare provider before making any changes to your treatment plan.

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