How Long Should You Wait to Take Sleep Aids After Laxatives? - Pharmacology

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How long should the interval be between taking sedative sleeping pills and Lyrica?


Hello, Doctor! I found this website where I can inquire about medication usage because I have long-term insomnia and anxiety.
My doctor prescribed me 3 mg of Mirtazapine, which I take before bed, and sometimes I also take one green FM2 (1 mg) to help me sleep.
However, I also suffer from severe constipation, so occasionally I take Laxative and Qingli Piao before bed.
I usually take the sleeping pills 1 to 2 hours after taking the laxative.
I am wondering if the sedative effects are causing my constipation.
How long should I wait after taking the laxative before taking the sleeping pills to avoid affecting the laxative's efficacy?

Xiao Na, 20~29 year old female. Ask Date: 2012/10/18

Dr. Liu Huiya reply Pharmacology


Hello: There are many causes of constipation.
You can first examine your lifestyle and dietary habits, such as whether you exercise less, drink insufficient water, consume fewer high-fiber foods and fruits and vegetables, or are on a diet for weight loss.
Additionally, work, academic pressures, or surrounding environmental stressors may contribute to your condition.
If these factors are ruled out and you still experience severe constipation, it may be necessary to consider underlying medical conditions or the effects of other medications.
Insomnia and anxiety can lead to dysregulation of the autonomic nervous system, which may contribute to your constipation.
Certain medications that affect gastrointestinal motility are also more likely to cause constipation as a side effect.
While sleeping pills have muscle relaxant properties, they typically do not cause significant constipation issues and do not interfere with the efficacy of laxatives (such as Lactulose or polyethylene glycol).
Therefore, these two types of medications can be taken together at bedtime.

Reply Date: 2012/10/18

More Info


When considering the timing of taking sleep aids after using laxatives, it is essential to understand how these medications work and their potential interactions. Laxatives, such as those you mentioned (e.g., Laxative Comfort and Clear), are designed to stimulate bowel movements, while sleep aids like Melatonin (牟靜) and FM2 are intended to help with sleep onset and maintenance.
Generally, it is advisable to wait at least 1 to 2 hours after taking a laxative before consuming a sleep aid. This waiting period allows the laxative to begin its action in the digestive system without interference from the sedative effects of the sleep medication. Taking them too close together could potentially lead to increased sedation or gastrointestinal discomfort, as both types of medications can affect the body in different ways.

It's also important to consider the side effects of the medications. Some sleep aids can cause drowsiness, dizziness, or gastrointestinal issues, which may exacerbate any discomfort you are experiencing from constipation or the effects of the laxative. If you find that the sleep aids are contributing to your constipation, it may be worth discussing alternative options with your healthcare provider.
In terms of the specific medications you mentioned, Melatonin is a natural hormone that regulates sleep-wake cycles and is generally considered safe for short-term use. However, it can still cause side effects in some individuals, including changes in mood or gastrointestinal upset. FM2, which contains a combination of ingredients, may also have sedative effects that could interact with the laxative.

If you are experiencing chronic insomnia and anxiety, it may be beneficial to explore additional treatment options beyond medication. Cognitive Behavioral Therapy for Insomnia (CBT-I) is a highly effective non-pharmacological approach that addresses the underlying causes of insomnia and can lead to long-term improvements in sleep quality. Additionally, lifestyle changes such as regular exercise, a balanced diet, and good sleep hygiene practices can significantly enhance sleep quality.

Lastly, if you are frequently relying on laxatives, it is crucial to address the underlying cause of your constipation. Chronic use of laxatives can lead to dependency and may worsen bowel function over time. A healthcare provider can help you develop a comprehensive plan to manage both your sleep issues and gastrointestinal health.

In summary, waiting 1 to 2 hours after taking a laxative before using a sleep aid is a prudent approach. However, it is essential to consult with your healthcare provider for personalized advice, especially if you are experiencing ongoing issues with sleep and constipation. They can help you find the most effective and safe treatment options tailored to your specific needs.

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