Do Cough Syrups Affect Urine Test Results in Infants? - Pediatrics

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Will this medication affect urine test results?


Hello, Dr.
Hsiao! My sister is currently eight months old.
Five days ago, she had a fever of 37.5 degrees Celsius at midnight and went to the emergency room.
A urine test was performed, and she had taken cough syrup two hours prior, which contains the following ingredients: dl-methylephedrine hydrochloride, chlorpheniramine maleate, and guaifenesin.
In the morning, she had a fever and took ibuprofen to reduce it.
I would like to know if the ingredients in these two medications could affect the results of the urine test.
The doctor mentioned today that the report was unusual, as the bacteria count was still within the normal range (abnormal would be greater than or equal to 15, but my sister only had 10), yet the white blood cell count was 150,000.
The doctor asked if she had been given any antibiotics before the urine test.
So, I would like to ask if the two medications I mentioned could influence the urine test results.
Additionally, my sister is scheduled for an ultrasound of her kidneys and bladder on Wednesday, but she is still taking the following cold medications (pyrilamine, cefixime, and bioferrin).
I am unsure if these ingredients could affect the ultrasound results.

Zhuang Tai Tai, 20~29 year old female. Ask Date: 2012/11/05

Dr. Xiao Kaiwen reply Pediatrics


The medications Xikening and Shuyitong will not affect urine test results.
Periactin, Cefx, and Biofermin will not impact the results of a kidney ultrasound.
A urine test showing 150,000 white blood cells? I really don't understand what that means.

Reply Date: 2012/11/05

More Info


Cough syrups, particularly those containing ingredients like dl-methylephedrine hydrochloride, chlorpheniramine maleate, and glyceryl guaiacolate, are generally not known to significantly affect urine test results in infants. The primary purpose of a urine test is to evaluate the presence of substances such as glucose, protein, ketones, and signs of infection, including white blood cells and bacteria. The ingredients in the cough syrup you mentioned are primarily aimed at alleviating cough and cold symptoms and do not typically interfere with the biochemical markers that are assessed in a standard urine analysis.

In your case, the urine test results showed a white blood cell count of 150,000, which is indeed quite high, indicating a potential infection or inflammation in the urinary tract. However, the presence of cough syrup ingredients is unlikely to be the cause of this elevated white blood cell count. It is important to note that the presence of bacteria in the urine is also a critical factor in diagnosing urinary tract infections (UTIs). Since your daughter’s bacterial count was within normal limits, it suggests that while there may be inflammation (as indicated by the high white blood cell count), there may not be a significant bacterial infection at this time.

Regarding the ultrasound of the kidneys and bladder, the medications your daughter is taking, including periactin, Cefx, and biofermin, are also not expected to interfere with the ultrasound results. Ultrasound imaging relies on sound waves to create images of the organs and does not typically get affected by the presence of medications in the body. However, it is always advisable to inform the healthcare provider about any medications being taken prior to the ultrasound, as they may have specific protocols or considerations based on the patient's medical history.

In summary, the cough syrups and other medications your daughter has been taking are not likely to affect the urine test results or the upcoming ultrasound. However, the elevated white blood cell count should be followed up with your pediatrician, as it may warrant further investigation to rule out any underlying issues, such as a urinary tract infection or other inflammatory conditions. It is crucial to ensure that your daughter stays well-hydrated, especially since she is primarily breastfed and may not be getting enough fluids, which can contribute to concentrated urine and potential crystal formation. If you have any further concerns or if her symptoms persist, please consult your pediatrician for tailored advice and management.

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