Hypertension Medications and Breastfeeding: What New Moms Need to Know - Pharmacology

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Medications for hypertension and breastfeeding?


Hello, I am a new mom who just had a cesarean section about two weeks ago.
Due to preeclampsia, my baby was born early, and the doctor suspects that I have chronic hypertension, so they prescribed antihypertensive medication for me.
I would like to know if these medications will affect my breastfeeding and my baby.
I am taking hydralazine HCl (Apresoline) 50 mg and nifedipine (Nifecard) 10 mg (the doctor said to take this one when my blood pressure is very high).
If I take these medications, will my blood pressure rebound even higher if I miss a dose?

Xiao Ting, 30~39 year old female. Ask Date: 2012/12/20

Dr. Chen Shuzi reply Pharmacology


Hello, Xiao Ting: Regarding the current medication issues: 1.
According to the literature, the use of Hydralazine HCl (Apresoline) during breastfeeding is considered appropriate.
However, Nifedipine can be secreted into breast milk, and although it is still uncertain whether it affects infants, if the mother must use Nifecardia (nifedipine) during breastfeeding, she must discontinue breastfeeding.
2.
Clinical studies emphasize that using short-acting nifedipine to rapidly lower blood pressure can easily lead to adverse effects such as cerebral, renal, and myocardial ischemia.
As early as 1985, the U.S.
Food and Drug Administration (FDA) recommended that using short-acting nifedipine to treat hypertensive emergencies is both unsafe and ineffective, while no concerns regarding increased risk have been found with long-acting nifedipine.

Reply Date: 2012/12/20

More Info


When it comes to managing hypertension in new mothers, especially those who are breastfeeding, it is crucial to understand the implications of the medications prescribed. You mentioned that you are taking Hydralazine HCl (Apresoline) and Nifedipine (Nifecardia) for your hypertension, and you are concerned about their effects on breastfeeding and your baby.


Hydralazine and Breastfeeding
Hydralazine is generally considered safe for use during breastfeeding. Studies have shown that it is excreted in breast milk in small amounts, and the levels are not expected to cause any adverse effects in breastfed infants. The American Academy of Pediatrics classifies Hydralazine as a medication that is usually compatible with breastfeeding. Therefore, if your doctor has prescribed this medication, it is likely because they believe the benefits outweigh any potential risks.


Nifedipine and Breastfeeding
On the other hand, Nifedipine, particularly the short-acting formulations, is a bit more complicated. While it is also excreted in breast milk, the effects on breastfeeding infants are not as well-studied. The long-acting formulations of Nifedipine are generally preferred for managing hypertension, as they provide more stable blood pressure control and have a lower risk of causing sudden drops in blood pressure. If your doctor has advised you to take Nifedipine only when your blood pressure is very high, it may be a precautionary measure to avoid potential spikes in blood pressure that could occur if you stop taking your medication altogether.


Blood Pressure Management
You expressed concern about your blood pressure rebounding if you do not take your medication. It is essential to manage hypertension effectively, especially after childbirth, as uncontrolled high blood pressure can lead to serious complications for both you and your baby. If your blood pressure readings are consistently high, it is crucial to follow your doctor's advice regarding medication. Abruptly stopping your medication can indeed lead to a rebound effect, causing your blood pressure to rise significantly. Therefore, it is advisable to maintain a dialogue with your healthcare provider about your medication regimen and any concerns you may have.


General Recommendations
1. Monitor Your Blood Pressure: Keep track of your blood pressure readings regularly. If you notice significant fluctuations or consistently high readings, contact your healthcare provider.

2. Discuss with Your Doctor: If you have concerns about the medications you are taking, especially regarding breastfeeding, do not hesitate to discuss these with your doctor. They may consider adjusting your medication or switching to alternatives that are safer for breastfeeding.

3. Lifestyle Modifications: Alongside medication, consider lifestyle changes that can help manage your blood pressure. These include maintaining a healthy diet, engaging in regular physical activity (as permitted post-delivery), and managing stress.

4. Breastfeeding Support: If you have concerns about breastfeeding while on medication, consider reaching out to a lactation consultant. They can provide guidance and support to ensure that both you and your baby are healthy.

In conclusion, while Hydralazine is generally safe for breastfeeding, caution is advised with Nifedipine. Always consult your healthcare provider regarding any changes in your medication or if you have concerns about your health and your baby's health. Your well-being is paramount, and managing your hypertension effectively is crucial for both you and your newborn.

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