Vitamin C Dosage Recommendations for Patients with Favism

Q: Vitamin C Dosage Recommendations for Patients with Favism

Dear： Vitamin C is classified as a low-risk medication on the "safe (or unsafe) medication list" for patients with G6PD deficiency. <br>Since G6PD deficiency is categorized by severity, it can be safely taken in cases of class II or III (unless in high doses). <br>However, there

The dosage of vitamin C for individuals with G6PD deficiency (Favism) should be approached with caution. It is important to consult a healthcare professional for personalized recommendations, as excessive vitamin C intake may lead to oxidative stress and hemolytic anemia in susceptible individuals

Hello, I would like to ask the doctor about the dosage of vitamin C for patients with favism.
Most information only states that high doses should be avoided.
Would taking a vitamin C effervescent tablet (180 mg) be considered excessive? Thank you!

Liu Xiansheng, 20~29 year old female. Ask Date: 2013/03/18

Dr. Liao Lingmei reply Pharmacology

Dear: Vitamin C is classified as a low-risk medication on the "safe (or unsafe) medication list" for patients with G6PD deficiency.
Since G6PD deficiency is categorized by severity, it can be safely taken in cases of class II or III (unless in high doses).
However, there is limited literature confirming what constitutes a high dose, but generally, a dosage exceeding 2g (2000 milligrams) is considered high.
I hope this response meets your satisfaction.
Wishing you all the best for your health and happiness!

Reply Date: 2013/03/18

More Info

When it comes to vitamin C dosage recommendations for patients with Favism, it is essential to understand the unique considerations for individuals with this condition. Favism, or G6PD deficiency, is a genetic disorder that affects red blood cell function and can lead to hemolytic anemia when exposed to certain triggers, including certain foods like fava beans and some medications.
Vitamin C (ascorbic acid) is a vital nutrient that plays several roles in the body, including acting as an antioxidant, aiding in collagen synthesis, and enhancing the immune system. However, for individuals with G6PD deficiency, there is a concern regarding the potential oxidative stress that high doses of vitamin C may cause. High doses of vitamin C can lead to increased oxidative stress, which could potentially trigger hemolysis in susceptible individuals.

The general recommendation for vitamin C intake for adults is about 65 to 90 mg per day, with an upper limit of 2,000 mg per day. However, for patients with G6PD deficiency, it is often advised to avoid high doses of vitamin C, particularly doses exceeding 500 mg per day, as this could pose a risk of hemolytic episodes.
Regarding the specific product you mentioned, a vitamin C effervescent tablet containing 180 mg of vitamin C is generally considered safe for most individuals, including those with G6PD deficiency, as long as it is taken within the recommended daily allowance. However, it is crucial to monitor for any adverse reactions, especially if the patient has a history of sensitivity to vitamin C or has experienced hemolytic episodes in the past.

It is also important to consider the total daily intake of vitamin C from all sources, including dietary sources. Foods rich in vitamin C, such as citrus fruits, strawberries, kiwi, bell peppers, and broccoli, should be included in the diet, but the total intake should not exceed the recommended levels for individuals with G6PD deficiency.

In conclusion, for patients with Favism, it is advisable to keep vitamin C intake within the standard recommended levels, ideally not exceeding 500 mg per day. The 180 mg effervescent tablet should be safe, but it is always best to consult with a healthcare provider or a registered dietitian who can provide personalized recommendations based on the individual's health status and dietary needs. Regular monitoring and open communication with healthcare professionals are essential to ensure safety and health management for individuals with G6PD deficiency.

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