Long-Term Medication Side Effects for High Uric Acid Levels?

Q: Long-Term Medication Side Effects for High Uric Acid Levels?

Hello Ms. <br>Li： Your father has elevated uric acid levels and hypertension, which can easily lead to urate nephropathy. <br>Therefore, both uric acid and blood pressure need to be strictly controlled to prevent or delay the onset of this condition. <br>Certain sedatives or slee

What are the side effects of long-term medication for hyperuricemia?

Hello, I would like to ask a few questions.
My father is seventy-two years old and has been experiencing severe uric acid issues over the past year or two, which has led to arthritis and mobility difficulties.
He has been on medication for over a year, as he also has high blood pressure.
Recently, he was hospitalized due to a gastric ulcer but has improved somewhat.
However, he has been frequently mentioning that he sees strange things and talks in his sleep at night.
A friend told me that this could be a sign of hallucinations due to taking too much sedative medication.
Is that true? Additionally, I came across an article titled "New Treatments for Degenerative Arthritis." Would this be effective for arthritis caused by uric acid? I hope to receive a response.
Thank you very much.

Li, 20~29 year old female. Ask Date: 2002/04/27

Dr. Guo Conghuai reply Internal Medicine

Hello Ms.
Li: Your father has elevated uric acid levels and hypertension, which can easily lead to urate nephropathy.
Therefore, both uric acid and blood pressure need to be strictly controlled to prevent or delay the onset of this condition.
Certain sedatives or sleeping medications may have specific side effects, so it is advisable to consult the prescribing physician.
The treatment approaches for degenerative arthritis and gouty arthritis are different.
It is recommended to consult a specialist.

Reply Date: 2002/04/27

More Info

Long-term medication for high uric acid levels, particularly in the context of gout and related conditions, can indeed have various side effects, especially in elderly patients like your father. It is essential to understand the medications being used, their potential side effects, and the overall management of his health conditions.

Medications for High Uric Acid Levels
The most commonly prescribed medications for managing high uric acid levels include allopurinol and febuxostat. These medications work by inhibiting the production of uric acid in the body. While effective, they can have side effects, including:
1. Skin Reactions: Some patients may experience rashes or allergic reactions.

2. Gastrointestinal Issues: Nausea, diarrhea, or abdominal pain can occur.

3. Liver Function: Regular monitoring of liver enzymes is necessary, as these medications can affect liver function.

4. Kidney Function: High uric acid levels can lead to kidney stones, and medications can sometimes exacerbate kidney issues.

In your father's case, given his history of hypertension and a recent hospitalization for a gastric ulcer, it is crucial to consider the interactions and cumulative effects of all medications he is taking. For instance, non-steroidal anti-inflammatory drugs (NSAIDs) used for arthritis pain can further irritate the stomach lining, especially in someone with a history of ulcers.

Neurological Symptoms
The symptoms your father is experiencing, such as seeing strange things and talking in his sleep, could potentially be linked to several factors:
1. Medication Side Effects: Some medications, particularly those affecting the central nervous system (like certain pain relievers or sedatives), can cause hallucinations or altered mental states, especially in older adults. If he is taking any sedatives or tranquilizers, these could be contributing to his symptoms.

2. Delirium or Dementia: Older adults are at risk for cognitive decline, which can manifest as confusion, hallucinations, or changes in behavior. This could be exacerbated by medication side effects or underlying health issues.

3. Electrolyte Imbalances: Conditions like dehydration or imbalances in electrolytes (which can occur with kidney issues or certain medications) can also lead to confusion and altered perceptions.

Management and Recommendations
1. Medication Review: It is crucial to have a healthcare provider review all medications your father is taking. This includes assessing for potential interactions and side effects that could be contributing to his neurological symptoms.

2. Regular Monitoring: Given his age and multiple health conditions, regular monitoring of kidney and liver function, as well as cognitive assessments, is essential. Blood tests can help determine if any medications are adversely affecting his health.

3. Diet and Lifestyle Changes: Alongside medication, dietary changes can significantly impact uric acid levels. Reducing purine-rich foods (like red meat, shellfish, and sugary beverages) and increasing hydration can help manage uric acid levels.

4. Alternative Treatments for Arthritis: Regarding the article on new treatments for degenerative arthritis, it is essential to consult with a healthcare provider before starting any new treatment. Some newer therapies may be effective for joint pain but should be evaluated in the context of your father's overall health and existing conditions.

5. Consult a Specialist: If the hallucinations and sleep disturbances persist, it may be beneficial to consult a neurologist or geriatric specialist. They can provide a more comprehensive evaluation and recommend appropriate interventions.

In conclusion, while managing high uric acid levels is crucial for preventing gout and related complications, it is equally important to monitor and manage the side effects of long-term medication use, especially in elderly patients. Regular consultations with healthcare providers can ensure that your father's treatment plan is safe and effective, addressing both his physical and cognitive health needs.

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