Invega: Is Excessive Salivation a Common Side Effect?

Invega, known generically as paliperidone, is an atypical antipsychotic medication primarily used to treat schizophrenia and schizo

Does Invega have the side effect of "increased salivation"? Thank you.

Ada, 30~39 year old female. Ask Date: 2013/05/31

Dr. Liu Huiya reply Pharmacology

According to pre-marketing research reports on this medication, the incidence of adverse reactions in patients with schizophrenia using Invega is reported to be 2% or higher, with the rate of adverse reactions increasing with dosage.
Among these reports, excessive salivation was noted.
However, the majority of the increased incidence of adverse reactions was primarily observed at the 12 mg dosage, while some cases were noted at the 9 mg dosage.
This indicates that the likelihood of experiencing drooling increases when the dosage is 9 mg or higher.

Reply Date: 2013/05/31

More Info

Invega, known generically as paliperidone, is an atypical antipsychotic medication primarily used to treat schizophrenia and schizoaffective disorder. As with many medications in this class, Invega can have a range of side effects, and one of the less commonly discussed side effects is excessive salivation, or sialorrhea.

Based on clinical studies and patient reports, it is noted that approximately 4% of individuals taking Invega may experience excessive salivation. This side effect can be particularly bothersome for some patients, as it can lead to discomfort and social embarrassment. The mechanism behind this side effect is not entirely understood, but it is thought to be related to the drug's action on neurotransmitter systems, particularly its effects on dopamine and serotonin pathways, which can influence salivary gland function.

When considering the side effects of Invega, it is essential to recognize that individual responses to medication can vary significantly. While some patients may experience excessive salivation, others may not encounter this issue at all. Additionally, if a patient is taking multiple medications, it can complicate the attribution of side effects to a specific drug. For instance, if a patient is on other antipsychotics or medications that can also influence salivation, it may be challenging to determine whether Invega is the sole cause of this side effect.

If you or someone you know is experiencing excessive salivation while taking Invega, it is crucial to consult with a healthcare provider. They can assess the situation, consider the overall medication regimen, and determine the best course of action. This might include adjusting the dosage, switching to a different medication, or implementing strategies to manage the side effect, such as using oral rinses or medications that can help reduce salivation.

It is also important to note that abruptly stopping or changing medications without professional guidance can lead to withdrawal symptoms or a worsening of the underlying condition. Therefore, any changes to medication should always be done under the supervision of a qualified healthcare professional.

In summary, while excessive salivation is a recognized side effect of Invega, it is relatively uncommon and varies among individuals. If this side effect occurs, it is advisable to discuss it with a healthcare provider to explore potential solutions and ensure that the treatment plan remains effective and tolerable.

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