Does Invega Cause Increased Salivation? Side Effects

Invega, known generically as paliperidone, is an atypical antipsychotic medication primarily used to treat schizophrenia and schizoaffective

Hello, may I ask if the medications Invega 3mg and 6mg have the side effect of increased salivation after administration?

Xiao V, 30~39 year old female. Ask Date: 2013/06/07

Dr. Ding Shuyan reply Psychiatry

According to the literature, approximately 4% of individuals taking Invega may experience excessive salivation as a side effect.
If you are certain that you are only taking Invega as your antipsychotic medication, then it is more likely that this side effect is caused by Invega.
This statement is made because sometimes physicians may prescribe more than one antipsychotic medication, and the possibility of side effects from a second or even third antipsychotic cannot be ruled out.
It is also advisable not to abruptly discontinue the medication; it is better to discuss potential solutions with your physician.
Wishing you all the best, Dr.
Ding Shuo-Yan.

Reply Date: 2013/06/07

More Info

Invega, known generically as paliperidone, is an atypical antipsychotic medication primarily used to treat schizophrenia and schizoaffective disorder. One of the concerns associated with the use of antipsychotic medications, including Invega, is the potential for various side effects, including increased salivation or sialorrhea.

Research indicates that approximately 4% of patients taking Invega may experience increased salivation as a side effect. This side effect can be particularly bothersome for some individuals, as it may lead to discomfort or social embarrassment. The mechanism behind this side effect is not entirely understood, but it is thought to be related to the drug's action on neurotransmitter systems, particularly the modulation of dopamine and serotonin pathways in the brain.
Invega works by blocking certain receptors in the brain, including dopamine D2 receptors and serotonin 5-HT2A receptors. While this action helps alleviate symptoms of psychosis, it can also disrupt the normal balance of neurotransmitters that regulate salivation. Increased salivation can occur due to overstimulation of the salivary glands or changes in the autonomic nervous system's regulation of these glands.

It's important to note that if you are taking Invega and experience increased salivation, it is crucial not to stop the medication abruptly without consulting your healthcare provider. Discontinuing antipsychotic medications suddenly can lead to withdrawal symptoms or a resurgence of psychiatric symptoms. Instead, discussing your concerns with your doctor is the best course of action. They may suggest adjusting the dosage, switching to a different medication, or implementing strategies to manage the side effect.

In addition to increased salivation, Invega can cause other side effects, including weight gain, sedation, and metabolic changes. Patients should be monitored regularly for these potential side effects, especially if they have pre-existing conditions that may be exacerbated by these effects.

In conclusion, while Invega can cause increased salivation in some patients, this side effect is relatively uncommon. If you are experiencing this or any other side effects, it is essential to communicate with your healthcare provider to determine the best management strategy tailored to your individual needs. They can help you weigh the benefits of the medication against the side effects and make informed decisions about your treatment plan.

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