Hand, Foot, and Mouth Disease: Common Concerns and Questions - Pediatrics

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Regarding enterovirus rashes!


Hello Dr.
Hsiao: Recently, both of my children contracted enterovirus one after the other.
My younger son started showing symptoms last Thursday, and my daughter developed symptoms two days later.
We suspect they may have been infected by the same virus, as both have hand, foot, and mouth disease.
I would like to ask:
1.
My son has healed from the mouth sores, but he still has some rashes on his arms and legs.
Does this mean he is completely recovered? When will the rashes subside?
2.
My daughter has been experiencing very slight body twitches while sleeping, but she remains in a sleeping state during these episodes.
Should this be considered myoclonic jerks?
3.
Before my daughter was hospitalized in the emergency department, blood tests showed her white blood cell count was 14,000 (she had a fever at the time), and the CRP indicated signs of inflammation.
Can enterovirus cause elevated white blood cell counts and inflammation?
4.
Is it true that enterovirus EV71 can only be diagnosed through observation? Are blood tests or any other examinations unable to provide a definitive diagnosis?

Zhuang Tai Tai, 30~39 year old female. Ask Date: 2013/07/10

Dr. Xiao Kaiwen reply Pediatrics


1.
After 7-10 days of enterovirus infection, the rashes on the hands and feet will stop appearing and gradually dry up and heal.

2.
Myoclonic jerks are similar to startle reflexes, so they generally have a larger amplitude.

3.
In the presence of any infection (whether viral or bacterial), laboratory tests can reveal elevated white blood cell counts and C-reactive protein (CRP) levels.

4.
To confirm the presence of enterovirus type EV71, observation alone is insufficient; it requires specialized serological antibody testing or throat and rectal viral swab cultures, which are performed in specialized laboratories when necessary.
Any form of enterovirus infection can potentially lead to severe illness, but the likelihood is higher with enterovirus type EV71.
Therefore, once diagnosed with an enterovirus infection, careful monitoring for any signs of severe illness is essential.

Reply Date: 2013/07/10

More Info


Hand, Foot, and Mouth Disease (HFMD) is a common viral infection primarily affecting young children, typically caused by enteroviruses, with Enterovirus 71 (EV71) being one of the more severe strains. Your concerns regarding your children’s symptoms are valid, and I will address each of your questions based on current medical understanding.

1. Recovery from HFMD: It’s great to hear that your son’s mouth sores have healed. However, the presence of rashes on his arms and legs indicates that he may still be in the recovery phase of HFMD. The rashes associated with HFMD can last for several days to a week after other symptoms have resolved. Generally, the rashes will gradually fade, and you should monitor them for any changes. If the rashes worsen or if new symptoms arise, it would be prudent to consult a pediatrician.

2. Sleep Movements in Your Daughter: The very mild twitching or movements your daughter exhibits while sleeping could be benign and may not necessarily indicate a serious condition. These movements can sometimes be related to normal sleep cycles or could be a form of myoclonic jerks, which are brief, involuntary muscle contractions. If these movements are infrequent and not associated with any other concerning symptoms (such as prolonged episodes of unresponsiveness), they may not be a cause for alarm. However, if you notice an increase in frequency or severity, or if they disrupt her sleep significantly, it would be wise to discuss this with her pediatrician.

3. Elevated White Blood Cell Count and Inflammation: Yes, enteroviral infections, including HFMD, can lead to an elevated white blood cell count and signs of inflammation, as indicated by the CRP (C-reactive protein) levels. The body’s immune response to the viral infection can cause these changes, which are common in many viral illnesses. The white blood cell count of 14,000 is slightly elevated, especially in the context of fever, which suggests that the body is responding to an infection. Monitoring these levels over time can help assess the resolution of the infection.

4. Diagnosis of EV71: Diagnosing specific strains of enteroviruses, including EV71, typically relies on laboratory testing, which may include PCR (polymerase chain reaction) testing of throat swabs, stool samples, or cerebrospinal fluid in more severe cases. However, in many instances, especially in mild cases of HFMD, the diagnosis is made clinically based on the characteristic symptoms and rash. While laboratory confirmation can be helpful, it is not always necessary for management, especially if the clinical picture is clear.

In summary, HFMD is usually a self-limiting condition, and supportive care is often sufficient. Ensure your children stay hydrated and comfortable, and monitor their symptoms closely. If you have any concerns about their recovery or if new symptoms develop, do not hesitate to reach out to their healthcare provider for further evaluation and guidance.

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