Does Finasteride Increase Estrogen Levels in Men? Hormonal Balance

Q: Does Finasteride Increase Estrogen Levels in Men? Hormonal Balance

Dear： The pharmacological action of Finasteride is to inhibit a reductase that converts testosterone into dihydrotestosterone (DHT). <br>In clinical studies involving patients, there were no significant changes in the levels of androgens, anti-androgens, estrogens, anti-estrogens

Ropivacaine & Estrogen

I would like to ask the doctor whether taking Finasteride increases estrogen levels in men.
The package insert states that "Finasteride has no affinity for androgen receptors and does not exhibit any androgenic, anti-androgenic, estrogenic, anti-estrogenic, or progestational activity." However, I have also heard that "because Finasteride inhibits androgens, it alters the hormonal balance in the body, which may indirectly lead to an increase in estrogen levels in men." Which of the above statements is correct? Thank you!

TT, 30~39 year old female. Ask Date: 2013/07/17

Dr. Liao Lingmei reply Pharmacology

Dear: The pharmacological action of Finasteride is to inhibit a reductase that converts testosterone into dihydrotestosterone (DHT).
In clinical studies involving patients, there were no significant changes in the levels of androgens, anti-androgens, estrogens, anti-estrogens, or progestogens during the medication period, which is why the product insert states this.
However, this medication has been on the market for many years, and among patients taking Finasteride, there have been reports of various degrees of serious side effects that may be related to hormonal changes in the body.
These include decreased libido, erectile dysfunction, ejaculation disorders (reduced ejaculate volume), gynecomastia, and male breast cancer.
This leads to the inference that the medication may cause increases in testosterone and estradiol, resulting in the aforementioned side effects.
I hope this response meets your satisfaction.
Wishing you health and happiness!

Reply Date: 2013/07/17

More Info

Finasteride, commonly known by its brand name Propecia, is primarily used to treat male pattern baldness and benign prostatic hyperplasia (BPH). It works by inhibiting the enzyme 5-alpha reductase, which converts testosterone into dihydrotestosterone (DHT), a more potent androgen. The question of whether Finasteride increases estrogen levels in men is a nuanced one, and it requires a deeper understanding of hormonal balance and the drug's pharmacological effects.

To address the claims made about Finasteride: the official prescribing information states that Finasteride does not have any affinity for androgen receptors and does not exhibit androgenic, anti-androgenic, estrogenic, or anti-estrogenic activity. This means that, in theory, Finasteride should not directly increase estrogen levels. However, the hormonal system is complex, and changes in one hormone can lead to compensatory changes in others.

When Finasteride reduces DHT levels, there can be a relative increase in testosterone levels since less testosterone is being converted into DHT. Some studies suggest that this increase in testosterone can lead to an increase in estrogen levels, as testosterone can be aromatized (converted) into estrogen. This is particularly relevant in the context of hormonal balance; if testosterone levels rise while DHT levels fall, the body may adjust by increasing estrogen levels to maintain a certain equilibrium.

Moreover, anecdotal reports and some clinical observations have noted side effects associated with Finasteride, including decreased libido, erectile dysfunction, and gynecomastia (breast tissue development in men). These side effects could be indicative of altered estrogen levels or sensitivity, even if Finasteride does not directly increase estrogen production. The relationship between testosterone, DHT, and estrogen is intricate, and individual responses to hormonal changes can vary widely.

In summary, while Finasteride itself does not directly increase estrogen levels, its impact on testosterone and DHT can lead to changes in the overall hormonal balance, which might result in increased estrogen levels in some individuals. The assertion that Finasteride can indirectly lead to increased estrogen levels due to its effects on testosterone and DHT is plausible and supported by some clinical observations.

For men experiencing side effects while on Finasteride, it is essential to consult a healthcare provider. They can evaluate hormone levels and overall health to determine the best course of action. In some cases, adjusting the dosage or switching medications may be necessary to alleviate unwanted side effects while still addressing the primary concern, such as hair loss or prostate enlargement.

In conclusion, the relationship between Finasteride and estrogen levels in men is complex. While the drug does not directly increase estrogen, its effects on testosterone and DHT can lead to hormonal changes that may result in increased estrogen levels in some individuals. It is crucial for patients to discuss any concerns with their healthcare provider to ensure a balanced approach to treatment and to monitor for any potential side effects.

Similar Q&A

Understanding Hair Loss: Finasteride Effects and Male Hormone Levels

I'm sorry, doctor. I would like to ask you about my experience in college when I was very anxious and felt a lot of pressure, which led to hair loss at the front of my scalp. Later, I started taking finasteride 5/4 mg daily, and it seems that my hair loss has stopped. Howeve...

Dr. Lin Hexing reply Urology
Hello: The medication you are taking is indeed an effective treatment for male pattern baldness, as it is an inhibitor of the conversion of testosterone to its more potent form, dihydrotestosterone (DHT). Breast swelling, erectile dysfunction, and decreased libido may be side eff...

Understanding Male Pattern Baldness: Hormones, Causes, and Treatment Concerns

Hello Dr. Liao, I would like to ask you about male pattern baldness and its relation to elevated male hormones. What are the causes of increased male hormone levels, and is there any connection to a higher frequency of sexual activity? Additionally, are there any side effects a...

Dr. Liao Wenyu reply Dermatology
Hello: Male pattern baldness is related to male hormones. Taking Finasteride is generally safe, but there is a 1%-2% chance of affecting sexual function. Aside from that, there are no restrictions on diet or sexual activity. Liao Wenyu

Does Finasteride Increase Breast Tumor Risk in Women?

I am a female experiencing androgenetic alopecia and have been taking Finasteride (commonly known as Propecia) for nearly two years as directed by my physician. Recently, I underwent a breast ultrasound that revealed abnormalities, and a breast biopsy confirmed a benign cyst. Doe...

Dr. Wu Yuxin reply Dermatology
Ropei does not contain estrogen. I am not sure about other questions, but you can discuss them with your breast surgeon.

Does Weightlifting Increase DHT Levels and Accelerate Hair Loss?

Hello Doctor: After my military service, I noticed signs of male pattern baldness and have been prescribed Finasteride. Recently, I started working out and came across a report from Xinhua News stating that scientists have indicated that bodybuilders, due to prolonged training, e...

Dr. Zhang Zhibo reply Dermatology
Hello: Both testosterone and dihydrotestosterone (DHT) are factors that contribute to hair loss, with DHT being a more potent androgen derivative than testosterone. The medication you are taking, Finasteride, is an inhibitor of the enzyme 5α-reductase, which converts testosterone...