Medication Overdose Risks in Infants: A Parent's Guide - Pediatrics

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Hello Dr.
Hsiao,
I would like to ask you a question.
My baby is currently two months old and was born prematurely at 35 weeks.
Last Wednesday (the 21st), during a check-up, I mentioned to the doctor that he seemed to have a cold.
The doctor prescribed Ciprofloxacin syrup, 1 cc in the morning and evening.
Since he also received vaccinations that day (pneumococcal, DTaP, and rotavirus), I did not give him the medication that day.
The next day, I noticed that his cold seemed to worsen; his voice became lower and less audible.
I started administering the medication on Thursday evening and continued until Sunday morning for three days.
He vomited a few times, and I supplemented with 0.5 cc a few times.
Once, it was more severe; he kept vomiting, and I had to re-administer 0.5 cc about four or five times.
On Monday afternoon, since his voice had not improved, I took him to see another doctor (the original doctor would not be available until Wednesday).
The new doctor said he was not sick at all and advised me to stop giving him the medication, stating that the hoarseness was a side effect of the medication.
Today is Thursday, and his voice is still hoarse and quiet; he has not improved.

I would like to ask the doctor if this strong medication could affect his brain, as I am very concerned about potential impacts on his brain or other areas, especially since I have been giving him extra doses and am unsure how much he actually ingested.
Should I consult a specific specialty for further examination? I am really worried, and I would appreciate your response.
Thank you!

Miss Yang, 30~39 year old female. Ask Date: 2015/01/29

Dr. Xiao Kaiwen reply Pediatrics


The dosage of Shipilimin for infants has not been clearly established.
Hoarseness is unlikely to be related to the potency of the medication.
A consultation with a pediatric specialist at a medical center can be arranged for further evaluation.

Reply Date: 2015/01/29

More Info


When it comes to medication overdose in infants, it is essential for parents to understand the potential risks and side effects associated with the medications prescribed. In your case, your two-month-old baby, who was born prematurely at 35 weeks, was prescribed a medication called "希普利敏液" (likely referring to a form of antihistamine or similar medication) for what you believed to be a cold. You mentioned that you started administering the medication after a day of observation and that your baby experienced vomiting and a hoarse voice after taking the medication.

First and foremost, it is important to recognize that infants have different metabolic rates and sensitivities to medications compared to older children and adults. Their bodies process drugs differently, and what may be a standard dose for an adult can be excessive for an infant. In your case, the fact that your baby was vomiting after taking the medication could indicate that the dosage was too high or that the medication was not well tolerated by their system.
The hoarseness you observed could be a side effect of the medication itself, especially if it is an antihistamine, which can cause dryness of the mucous membranes and throat. This side effect is generally not harmful but can be distressing for both the infant and the parents. It is unlikely that this would lead to any long-term effects on the brain or other organs, especially if the medication was stopped and the infant is otherwise healthy.

Given that your baby is still experiencing hoarseness and has not returned to their normal vocalization, it would be prudent to consult a pediatrician or an ear, nose, and throat (ENT) specialist. They can assess whether there is any underlying issue that needs to be addressed, such as irritation of the vocal cords or any other complications from the medication.

In terms of medication management, it is crucial to follow the prescribed dosage closely and to communicate any concerns with your healthcare provider. If you suspect that your baby has ingested more medication than prescribed, or if you notice any unusual symptoms, it is essential to seek medical attention immediately.
For future reference, when administering medication to infants, consider the following tips:
1. Always double-check dosages: Ensure that you are giving the correct amount as prescribed by the doctor. If you are unsure, do not hesitate to ask the pharmacist or doctor for clarification.

2. Monitor for side effects: Keep an eye on your baby for any adverse reactions after administering medication. If you notice anything unusual, contact your healthcare provider.

3. Avoid over-medication: If your baby vomits after taking medication, do not immediately re-administer the same dose without consulting a healthcare professional. They can advise you on the best course of action.

4. Seek second opinions: If you feel uncertain about a diagnosis or treatment plan, it is always acceptable to seek a second opinion from another healthcare provider.

5. Educate yourself: Understanding the medications your child is taking, including their potential side effects and interactions, can empower you as a parent to make informed decisions about their health.

In conclusion, while the concerns you have regarding your baby's medication are valid, it is essential to approach the situation with a clear understanding of the risks and to seek professional guidance when needed. Your baby's health and safety are paramount, and maintaining open communication with healthcare providers will help ensure that they receive the best possible care.

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