Does L-Arginine Increase Herpes Virus Activity and Trigger Recurrence? - Dermatology

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Herpes virus


Hello Dr.
Lee, I would like to ask if taking L-arginine will increase the activity of the herpes virus? I had shingles a few years ago and I'm wondering if taking L-arginine could cause a recurrence.

Lin Xiansheng, 30~39 year old female. Ask Date: 2015/05/18

Dr. Li Yufen reply Dermatology


Hello: L-arginine is classified as a dietary supplement.
The product precautions mention that individuals with glaucoma, herpes, myocardial infarction, coronary artery disease, or those with heart stents should avoid consuming arginine.
Thank you!

Reply Date: 2015/05/18

More Info


L-Arginine, an amino acid that plays a role in various physiological processes, has been a topic of discussion regarding its potential effects on herpes virus activity, particularly in individuals with a history of herpes infections, such as herpes simplex virus (HSV) or varicella-zoster virus (VZV), which causes shingles (herpes zoster).

Research suggests that L-Arginine may indeed have a stimulating effect on the replication of certain viruses, including herpes viruses. This is primarily because arginine is a precursor for the synthesis of nitric oxide, which can influence immune responses and viral replication. In the context of herpes viruses, some studies have indicated that higher levels of arginine may facilitate viral replication, potentially leading to an increased risk of outbreaks or recurrences in individuals with a history of herpes infections.

Conversely, another amino acid, L-Lysine, is often recommended as a dietary supplement to help manage herpes outbreaks. L-Lysine is thought to inhibit the absorption of L-Arginine in the body, thereby potentially reducing the frequency and severity of herpes outbreaks. The balance between these two amino acids is crucial; a diet high in arginine and low in lysine may create an environment conducive to herpes virus activity.

Given your history of shingles, it is prudent to approach the use of L-Arginine with caution. If you are considering taking L-Arginine supplements, it would be wise to consult with your healthcare provider first. They can provide personalized advice based on your medical history and current health status. Additionally, if you notice any signs of a herpes outbreak while taking L-Arginine, it is essential to seek medical advice promptly.

In summary, while L-Arginine has beneficial roles in the body, its potential to increase herpes virus activity and trigger recurrences is a valid concern, particularly for individuals with a history of herpes infections. Monitoring your diet and considering the balance of amino acids, especially in relation to L-Lysine, can be beneficial in managing your health. Always consult with a healthcare professional before starting any new supplement, especially if you have a history of viral infections.

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