Persistent Pain During Urination Despite Normal Urine Test Results - Urology

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Urinalysis results are normal, but there is pain during urination?


Hello, Dr.
Hsu: My issue has been ongoing for a long time.
Initially, I had a urinary tract infection, but I have not been able to fully resolve it.
At first, there were indeed white blood cells detected in my urine, and I have consulted many doctors.
Later on, my urine tests showed no signs of white blood cell inflammation, but I still experience pain when urinating.
The pain starts as the urine passes through the urethra, and sometimes the glans will itch, feeling like ants are crawling on it.
I visited a urology clinic, and the doctor asked me to get a prostate examination.
After the examination, they diagnosed me with prostatitis.
I have taken medication and received injections, but the results have been limited.
At a larger hospital, the physician disagreed with the diagnosis, and I am unsure how to proceed appropriately.

Xiao Feng, 40~49 year old female. Ask Date: 2015/07/27

Dr. Xu Weikai reply Urology


Xiaofeng: Hello, urinary tract infections are usually easy to treat.
The pain during urination may be due to scarring from a previous infection.
It takes a longer time for the tissue to fully heal before improvement is seen.
Patience is needed, and it's important to avoid reinfection.
Generally, symptomatic treatment is provided, such as pain relief and anti-inflammatory measures.
Some doctors recommend the long-term use of cranberry supplements (tablets, powders, or juice are all acceptable).

Reply Date: 2015/07/27

More Info


Persistent pain during urination, especially when urine tests return normal results, can be a frustrating and distressing experience. It is essential to understand that while urine tests can rule out certain conditions, they may not always provide a complete picture of what is happening in the urinary tract or related systems.
In your case, it seems that you have a history of urinary tract infections (UTIs) that have been treated, but the pain persists. This could be due to several reasons. One possibility is that you may be experiencing a condition known as chronic prostatitis or chronic pelvic pain syndrome (CP/CPPS). This condition can cause pain in the pelvic region, including during urination, even when there are no signs of infection in urine tests.
Chronic prostatitis can be categorized into different types, and the most common form, CP/CPPS, is often not associated with a bacterial infection. Symptoms can include pain during urination, pelvic pain, and discomfort in the genital area. The exact cause of CP/CPPS is not fully understood, but it may involve inflammation, nerve damage, or muscle tension in the pelvic area.

Another potential cause of your symptoms could be interstitial cystitis (IC), also known as painful bladder syndrome. IC is a chronic condition characterized by bladder pressure, bladder pain, and sometimes pelvic pain, which can lead to frequent urination and discomfort during urination. Like CP/CPPS, IC may not show any abnormalities in standard urine tests.

Given your symptoms, it is crucial to consider a comprehensive evaluation. Here are some steps you might take:
1. Follow-Up with a Urologist: If you haven't already, consider seeing a urologist who specializes in chronic pelvic pain or prostatitis. They may perform additional tests, such as a cystoscopy, to examine the bladder and urethra directly.

2. Pelvic Floor Physical Therapy: Sometimes, pelvic floor dysfunction can contribute to urinary pain. A physical therapist specializing in pelvic health can help address muscle tension and improve pelvic floor function.

3. Pain Management: Discuss pain management options with your healthcare provider. This may include medications to help manage pain or inflammation.

4. Lifestyle Modifications: Certain lifestyle changes, such as dietary adjustments, stress management techniques, and regular exercise, can help alleviate symptoms. Some patients find relief by avoiding irritants like caffeine, alcohol, and spicy foods.

5. Alternative Therapies: Some patients benefit from alternative therapies, such as acupuncture or mindfulness practices, which can help manage chronic pain.

6. Regular Monitoring: Keep a symptom diary to track when the pain occurs, its intensity, and any potential triggers. This information can be valuable for your healthcare provider in determining the best course of action.

In conclusion, persistent pain during urination despite normal urine test results can be attributed to several underlying conditions, including chronic prostatitis or interstitial cystitis. A thorough evaluation by a specialist, along with appropriate management strategies, can help address your symptoms and improve your quality of life. Always communicate openly with your healthcare provider about your symptoms and any concerns you may have, as this will aid in finding the most effective treatment plan for your situation.

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