HPV Vaccine: Safety Concerns and Protection Beyond Cervical Health - Obstetrics and Gynecology

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Regarding the HPV vaccine?


Hello Doctor, my family is currently encouraging me to receive the HPV vaccine, but I have a sensitive constitution and have experienced mild fever after previous vaccinations.
Is it suitable for me to receive the vaccine under these circumstances? Additionally, I would like to know if the protection offered by this vaccine is limited to the cervix, or if it also provides protection in other areas.
Lastly, I have a concern: about a month ago, I noticed a small bump on my vulva that is the same color as my skin (approximately the size of a comedo, but with a smooth surface).
I initially thought it would disappear on its own, but it has not, and it is neither painful nor itchy, and it does not seem to have grown.
Could this be a sign of a serious condition? Thank you, Doctor, for taking the time to respond.

Xiao Xiao, 20~29 year old female. Ask Date: 2015/09/01

Dr. Lü Lizheng reply Obstetrics and Gynecology


The HPV vaccine provides immune protection throughout the body, but it is limited to common virus types, with certain viruses still lacking protection.
It can protect against approximately 85% of the viruses.
If you have a unique constitution, please consult a physician before deciding whether to receive the vaccine.
Small protrusions on the vulva that do not increase in size or change color are usually benign, and you may seek a physician's evaluation.
Sincerely, Dr.
Li-Cheng Lu, Taoyuan Hospital.

Reply Date: 2015/09/01

More Info


The HPV vaccine is a crucial tool in preventing human papillomavirus (HPV) infections, which are linked to various cancers, including cervical cancer. Your concerns about the vaccine's safety, especially given your sensitivity to vaccines, are valid and worth discussing.

Firstly, regarding your previous experiences with vaccines and mild fever, it's important to note that mild side effects, such as fever, are common reactions to vaccinations. These reactions are typically a sign that your immune system is responding to the vaccine. However, if you have a history of severe allergic reactions or other significant adverse effects from vaccines, it would be wise to consult with your healthcare provider before proceeding with the HPV vaccine. They can assess your medical history and determine the best course of action for you.

As for the protective capabilities of the HPV vaccine, it primarily targets the high-risk HPV types that are most commonly associated with cervical cancer, such as types 16 and 18. However, the vaccine also provides protection against other HPV-related conditions, including genital warts and some other anogenital cancers. Recent studies have shown that the vaccine can reduce the incidence of HPV-related oropharyngeal cancers as well, which are cancers of the throat that can be caused by HPV. Therefore, while the primary focus is on cervical health, the vaccine offers broader protection against various HPV-related diseases.

Now, concerning the small bump you discovered on your vulva, it’s understandable to feel anxious about any new growths. While it’s difficult to provide a definitive diagnosis without a physical examination, there are several possibilities for what you might be experiencing. The bump could be a benign condition, such as a sebaceous cyst, a follicular cyst, or even a harmless skin tag. However, it’s also important to consider that HPV can cause genital warts, which may appear as small, flesh-colored bumps. Given that the bump has not changed in size or caused discomfort, it may not be a cause for immediate concern, but it is essential to have it evaluated by a healthcare professional. They can perform a thorough examination and, if necessary, conduct tests to determine the nature of the bump.

In summary, while the HPV vaccine is generally safe and effective, your personal health history should guide your decision to receive it. The vaccine provides protection against several HPV-related diseases beyond cervical cancer, and any new skin growths should be evaluated by a healthcare provider to rule out any serious conditions. It’s always best to consult with a medical professional who can provide personalized advice based on your health status and concerns.

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