How Soon Can I Get Pregnant After Ectopic Pregnancy Treatment? - Obstetrics and Gynecology

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After receiving methotrexate (MTX) treatment for an ectopic pregnancy, it is generally recommended to wait at least 3 months before attempting to conceive again. This allows time for the medication to clear from the body and for the reproductive system to return


Dear Doctor: I have an ectopic pregnancy.
In early December, I experienced heavy bleeding and underwent surgery, but the tissue report showed no embryonic tissue (the early gestational sac was also not visible).
My hCG levels continued to rise.
On December 16, I started receiving methotrexate (MTX) injections at a dose of 0.5 mg.
On December 18, I received the same dose of 0.5 mg, but the effect was poor, and my hCG levels continued to rise.
Therefore, on December 20, the dose was increased to 0.6 mg.
My pregnancy levels began to decrease after that.
I continued with 0.6 mg on December 22, 24, and 26, and while my levels continued to decline, the decrease was minimal, so my doctor decided to stop the MTX treatment.

I would like to ask how long it will take for me to be able to conceive again after the embryo shrinks and menstruation occurs.
Will this affect the fetus in future pregnancies? My attending physician mentioned that I could try to conceive after my next menstrual period, but I found articles online suggesting a wait of 3 months.
So, I would like to know what the optimal time frame is for trying to conceive again.
I am not young and am eager to have a second child.
Thank you, Doctor!

tina, 30~39 year old female. Ask Date: 2016/01/08

Dr. Cao Guotao reply Obstetrics and Gynecology


Hello, generally, it is considered that the process is properly managed only when the BHCG levels return to normal and menstruation resumes.
This indicates that there are no issues with trying to conceive.
Typically, a period of 2 to 3 months is more appropriate.
Wishing you good health.

Reply Date: 2016/01/08

More Info


After experiencing an ectopic pregnancy, it is understandable to have concerns about when it is safe to conceive again and how it may affect future pregnancies. The timeline for trying to conceive after an ectopic pregnancy can vary based on individual circumstances, including the treatment received and the body’s recovery.

In general, many healthcare providers recommend waiting for at least one menstrual cycle after the treatment of an ectopic pregnancy before attempting to conceive again. This allows your body to heal and ensures that your hormone levels return to normal. In your case, since you received methotrexate (MTX) treatment, it is particularly important to ensure that the medication has cleared from your system. Methotrexate can affect rapidly dividing cells, including those in a developing embryo, so waiting for a complete cycle is prudent.

Typically, the recommendation to wait for three months is more conservative and is often suggested to ensure that the body has fully recovered and that any potential effects of the medication have dissipated. However, if your healthcare provider has assessed your situation and feels that you can try to conceive after your next menstrual period, it may be appropriate to follow their guidance, especially if your HCG levels have returned to normal and you are feeling well.

Regarding the potential impact on future pregnancies, if you have fully recovered from the ectopic pregnancy and the treatment, there should not be any long-term effects on your fertility or the health of a future pregnancy. However, it is essential to monitor your health closely and maintain regular check-ups with your healthcare provider. They can provide personalized advice based on your medical history and current health status.

It is also important to consider that after an ectopic pregnancy, there may be an increased risk of another ectopic pregnancy in future pregnancies. This risk is particularly relevant if there are underlying factors such as previous pelvic infections, surgery, or conditions affecting the fallopian tubes. Therefore, if you do conceive again, early monitoring through blood tests and ultrasounds may be recommended to ensure that the pregnancy is developing normally within the uterus.

In conclusion, while many healthcare providers suggest waiting for one menstrual cycle after an ectopic pregnancy, it is crucial to follow the advice of your healthcare provider, who understands your specific situation. If you feel ready to try for another pregnancy and your doctor agrees, you can proceed with caution. Always prioritize your health and well-being, and do not hesitate to reach out to your healthcare provider with any concerns or questions you may have as you navigate this journey.

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