RU486: Timing and Effectiveness of the Two Doses

The first dose and the second dose of RU486?

Hello doctor, I took the RU486 prescribed by you at 2 AM on January 7th.
I am supposed to take the second dose about 36-48 hours later, and I haven't experienced many symptoms, just mild abdominal discomfort.
I had intercourse at 10 AM on January 8th.
Will the medication be ineffective? (I plan to take the second dose between 2 PM and 6 PM on January 8th.)

Yun, 20~29 year old female. Ask Date: 2016/01/08

Dr. Zhang Kunmin reply Obstetrics and Gynecology

Hello, based on your description, it generally should not have an impact.
However, after taking the abortion medication, you should return for a follow-up appointment to take prostaglandin medication 36 to 48 hours later.
If you experience any discomfort, hospitalization for observation may be necessary.
Within one to two weeks after taking the abortion medication, the patient must return for follow-up to confirm whether the embryo has been completely expelled through clinical examination, β-HCG measurement, and ultrasound scanning.
Thank you! Wishing you peace and health.
Dr.
Zhang

Reply Date: 2016/01/08

More Info

RU486, also known as mifepristone, is a medication used in medical abortions. It works by blocking the hormone progesterone, which is necessary for the continuation of a pregnancy. The effectiveness of RU486 is highly dependent on the timing and administration of the doses.

In your case, you took the first dose of RU486 at 2 AM on January 7th. The recommended protocol typically involves taking the second dose, usually misoprostol, 36 to 48 hours after the first dose. You mentioned that you plan to take the second dose between 2 PM and 6 PM on January 8th, which falls within the recommended timeframe.

Regarding your concern about having sexual intercourse on January 8th after taking the first dose of RU486, it is important to understand that the effectiveness of the medication is not immediately compromised by sexual activity. However, it is crucial to note that if you were to conceive again after taking RU486, it could lead to complications, as the medication is intended to terminate an existing pregnancy.

The effectiveness of RU486 is generally high when both doses are taken as prescribed. Studies have shown that when the regimen is followed correctly, the success rate for medical abortion is around 95-98%. It is also important to monitor for any side effects or symptoms that may arise after taking the medication, such as heavy bleeding, severe abdominal pain, or fever, as these could indicate complications.

If you have any concerns about the timing of your doses or the effectiveness of the medication, it is advisable to consult your healthcare provider. They can provide personalized guidance based on your specific situation and ensure that you are following the correct protocol for the medical abortion process.

In summary, as long as you take the second dose of RU486 within the recommended time frame, the medication should remain effective. Engaging in sexual activity after the first dose does not inherently cause the medication to fail, but it is essential to be cautious about the possibility of a new pregnancy. Always follow your healthcare provider's instructions and reach out to them if you have any questions or concerns regarding your treatment.

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