the Risks of Ciproxin for Stroke Survivors

Q: the Risks of Ciproxin for Stroke Survivors

Dear： The active ingredient of Ciproxin is Ciprofloxacin. <br>When discussing its relationship with stroke, it is important to note that the causes of stroke stem from cerebrovascular or cardiovascular issues. <br>However, the warning regarding "previous stroke" in relation to th

What is the relationship between CIPROXIN and stroke?

Dear Pharmacist: My father has been diagnosed with an internal illness and received a prescription from the hospital that includes CIPROXIN.
The warning on the prescription states that it should only be used if the therapeutic benefits outweigh the risks in patients with a history of stroke.
Since my father has had a minor stroke in the past, I am concerned about whether this will affect his treatment.

Zhou Wen, 30~39 year old female. Ask Date: 2016/01/22

Dr. Liao Lingmei reply Pharmacology

Dear: The active ingredient of Ciproxin is Ciprofloxacin.
When discussing its relationship with stroke, it is important to note that the causes of stroke stem from cerebrovascular or cardiovascular issues.
However, the warning regarding "previous stroke" in relation to this medication likely arises from adverse reaction reports concerning its effects on the nervous system.
Here are some points to consider:
1.
Ciprofloxacin may induce seizures, increase intracranial pressure, or manifest psychiatric symptoms.
The risk of these effects is heightened in patients with a history of epilepsy, cerebral aneurysms, acute renal failure, or those taking certain concomitant medications.
2.
Ciprofloxacin may cause sensory neuropathy or sensorimotor neuropathy.
If a patient has a history of these conditions, discontinuation of the medication is advised.
3.
Ciprofloxacin belongs to the fluoroquinolone class of antibiotics, which may lead to peripheral neuropathy.
This can occur early in treatment or may persist for several months to years after discontinuation.
Therefore, careful evaluation is warranted when considering its use.
These points summarize cases associated with this medication.
The warning on the prescription label (is it the medication bag?) is intended for physician reference, while the medication bag is for the patient or their family.
Currently, there is a heightened caution in the medical community regarding the use of antimicrobial agents, and prescriptions are typically made only when deemed necessary.
It is advisable to discuss this matter with your physician, as their extensive clinical experience may provide you with more satisfactory answers.
Wishing you health and happiness!

Reply Date: 2016/01/22

More Info

Ciprofloxacin, marketed under the brand name Ciproxin, is a fluoroquinolone antibiotic commonly used to treat various bacterial infections. However, its use in patients with a history of stroke, such as your father, requires careful consideration due to potential risks associated with the medication.

The warning regarding the use of Ciproxin in patients with a history of stroke is primarily rooted in the drug's side effect profile. Ciprofloxacin has been associated with several neurological side effects, including seizures, increased intracranial pressure, and psychiatric symptoms. For patients who have previously experienced a stroke, these risks can be particularly concerning.
1. Seizures: Ciprofloxacin can lower the seizure threshold, which means it may increase the likelihood of seizures occurring in susceptible individuals. If your father has a history of seizures or other neurological conditions, this risk is heightened.

2. Increased Intracranial Pressure: There are reports that fluoroquinolones can lead to increased intracranial pressure, which could exacerbate any existing neurological issues stemming from a prior stroke.

3. Peripheral Neuropathy: Ciprofloxacin can cause peripheral neuropathy, which may present as pain, tingling, or numbness in the extremities. For someone with a history of stroke, this could complicate their recovery and overall neurological health.

4. Psychiatric Effects: There have been instances of psychiatric side effects, including confusion, hallucinations, and agitation, particularly in older adults or those with pre-existing conditions. This could be particularly problematic for stroke survivors, who may already be dealing with cognitive changes.

Given these potential risks, the prescribing physician must weigh the benefits of using Ciproxin against these dangers. If the infection being treated is severe and the benefits of using Ciproxin outweigh the risks, the physician may decide to proceed with the prescription. However, close monitoring would be essential.

It is crucial to have an open dialogue with your father's healthcare provider. Discuss his medical history, including the stroke, and any other medications he may be taking. The physician may consider alternative antibiotics that do not carry the same level of risk for patients with a history of stroke.
In summary, while Ciproxin can be effective for treating bacterial infections, its use in stroke survivors necessitates a careful assessment of risks versus benefits. Always consult with a healthcare professional before starting or continuing any medication, especially in patients with complex medical histories.

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