the Incubation Period of Amoebic Meningoencephalitis - Neurology

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The incubation period for amoebic meningoencephalitis?


Hello Dr.
Lan: I occasionally perform nasal irrigation and have used untreated tap water for this purpose.
However, after learning that amoebic meningoencephalitis can lead to a very high mortality rate, I have some questions regarding the incubation period of this condition.
According to the CDC's online Q&A, the incubation period for amoebic meningoencephalitis is up to 7 days (URL: http://www.cdc.gov.tw/qa.aspx?treeid=5784355bfd011a1c&nowtreeid=391d623fe1bf1e5d).
However, I also came across a foreign case where the incubation period exceeded 7 days, lasting up to 2 months (URL: http://www.ettoday.net/news/20150409/490355.htm).
Therefore, I would like to ask Dr.
Lan how long the incubation period for amoebic meningoencephalitis can be, as I am somewhat concerned after having performed nasal irrigation recently.
Thank you.

SS, 20~29 year old female. Ask Date: 2016/02/24

Dr. Lan Shengxing reply Neurology


Dear SS, I hope you are no longer worried.
Regarding the incubation period, the literature we have read indicates the maximum range, but there is no absolute statement that nothing will happen beyond this date.
For issues related to nasal irrigation, please consult an otolaryngologist, as it is generally not recommended.
Best regards, Blue Saint Star.

Reply Date: 2016/02/24

More Info


Amoebic meningoencephalitis, primarily caused by the free-living amoeba Naegleria fowleri, is a rare but often fatal condition that can occur when contaminated water enters the body through the nose. This typically happens during activities such as swimming in warm freshwater lakes or using contaminated water for nasal irrigation. The incubation period for this disease is a critical aspect to understand, especially for individuals who may have been exposed to potential sources of infection.

The Centers for Disease Control and Prevention (CDC) indicates that the incubation period for Naegleria fowleri infection is generally between 1 to 9 days, with most cases presenting symptoms within 5 days after exposure. However, there are documented cases where the incubation period has extended beyond this typical range, leading to confusion and concern among those who may have been exposed. For instance, there have been reports of symptoms appearing as late as 2 weeks to even 2 months after exposure, although these are exceedingly rare.

The variability in the incubation period can be attributed to several factors, including the individual's immune response, the amount of amoeba exposure, and the specific strain of Naegleria fowleri. It is important to note that once symptoms begin, the disease progresses rapidly, often leading to severe neurological damage and death within a week or so. Symptoms typically start with headache, fever, nausea, and vomiting, and can quickly escalate to stiff neck, confusion, loss of balance, and seizures.

Given your concern about having washed your nose with untreated tap water, it is crucial to monitor for any symptoms associated with amoebic meningoencephalitis. If you experience any of the aforementioned symptoms, especially within a week or two after exposure, it is imperative to seek medical attention immediately. Early diagnosis and treatment are vital, although the prognosis remains poor in most cases.

In terms of prevention, it is advisable to avoid using untreated water for nasal irrigation. Boiling water for at least one minute or using distilled or sterile water can significantly reduce the risk of infection. Additionally, being cautious while swimming in warm freshwater bodies and avoiding submerging the head can further minimize exposure to Naegleria fowleri.

In conclusion, while the typical incubation period for amoebic meningoencephalitis is up to 7 days, there are exceptions where symptoms may appear later. If you have concerns about your health following nasal irrigation with untreated water, it is best to consult a healthcare professional for personalized advice and potential evaluation. Your awareness and proactive approach are essential in addressing any health risks associated with this rare but serious infection.

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