Immune System Issues in Atopic Dermatitis Management - Internal Medicine

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Questions about the immune system?


Hello Dr.
Gao: I would like to ask a question.
I have atopic dermatitis, which was relatively well-controlled for a while, but in the past few months, it has been recurring frequently, improving and then flaring up again.
I have seen a doctor, but the issue persists.
Some people say this is related to the immune system, and a clinic nurse mentioned that it might be my own cells attacking themselves.
I would like to know what I should do in this situation.
Thank you for your guidance!

Han Yu Qing, 30~39 year old female. Ask Date: 2016/02/29

Dr. Gao Jiankai reply Internal Medicine


Hello, thank you for your question.
Atopic dermatitis is indeed an issue related to the immune system, which is sensitive to stress and lifestyle habits.
Therefore, even with medication and topical treatments, atopic dermatitis may still exhibit fluctuations in severity.
On the other hand, the common cold is caused by viral infections, and individuals with compromised immune systems are more likely to experience recurrent infections or prolonged symptoms.
However, there is no direct relationship between the common cold and atopic dermatitis.
While atopic dermatitis is an immune system issue, it does not affect overall immunity, so individuals with atopic dermatitis are not more susceptible to colds.

I believe the recent fluctuations in weather have led to an increase in cold cases, and frequent colds are often the result of close contact and cross-infection.
To enhance immune function, it is recommended to maintain a regular lifestyle, including going to bed early, waking up early, and having a balanced diet, along with establishing a routine for physical exercise.
This will help stabilize the immune system, making it easier to control atopic dermatitis and reducing the likelihood of catching colds.
You might want to give this a try.

Best regards from the Allergy, Immunology, and Rheumatology Department of Changhua Hospital, Ministry of Health and Welfare.

Reply Date: 2016/02/29

More Info


Atopic dermatitis (AD), commonly known as eczema, is indeed closely linked to the immune system. It is a chronic inflammatory skin condition characterized by dry, itchy, and inflamed skin. The immune system plays a crucial role in the pathogenesis of atopic dermatitis, as it involves an imbalance in immune responses, particularly an overactive immune response to environmental triggers.

In individuals with atopic dermatitis, the skin barrier is often compromised due to genetic factors, leading to increased transepidermal water loss and susceptibility to irritants and allergens. This compromised barrier allows for easier penetration of allergens and microbes, which can trigger an immune response. The immune system, in turn, releases inflammatory mediators, leading to the characteristic symptoms of redness, itching, and swelling.

Your experience of having periods of control followed by flare-ups is common among those with atopic dermatitis. Various factors can contribute to these flare-ups, including environmental changes, stress, infections (like the common cold), and even dietary factors. While atopic dermatitis itself does not directly weaken the immune system, the stress and inflammation associated with flare-ups can make individuals more susceptible to infections, such as colds.

To manage your atopic dermatitis effectively, consider the following strategies:
1. Moisturization: Regularly applying a good moisturizer is essential. Look for products that are fragrance-free and designed for sensitive skin. Moisturizers help to restore the skin barrier and prevent dryness, which can trigger flare-ups.

2. Avoid Triggers: Identify and avoid potential triggers that worsen your condition. Common triggers include certain fabrics (like wool), soaps, detergents, and environmental factors (like pollen or pet dander). Keeping a diary of flare-ups may help you identify specific triggers.

3. Medication: Follow your doctor's recommendations regarding topical corticosteroids or other prescribed medications. These can help reduce inflammation during flare-ups. If you find that topical treatments are not effective, discuss alternative therapies with your healthcare provider.

4. Stress Management: Since stress can exacerbate atopic dermatitis, incorporating stress-reduction techniques such as mindfulness, yoga, or regular exercise may be beneficial.

5. Dietary Considerations: While the link between diet and atopic dermatitis is still being researched, some individuals find that certain foods can trigger their symptoms. Consider consulting with a dietitian to explore any potential dietary modifications.

6. Regular Follow-ups: Since you mentioned that you have seen a doctor but are still experiencing issues, it may be helpful to have regular follow-ups with a dermatologist who specializes in atopic dermatitis. They can provide tailored advice and adjust your treatment plan as needed.

7. Education: Understanding your condition is vital. Educate yourself about atopic dermatitis, its triggers, and management strategies. This knowledge can empower you to take control of your skin health.

In summary, while atopic dermatitis is indeed related to immune system issues, it is essential to adopt a comprehensive management approach that includes skincare, lifestyle modifications, and medical treatment. By working closely with your healthcare provider and implementing these strategies, you can improve your skin condition and reduce the frequency and severity of flare-ups.

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